NCT06970327Completed
Totally Laparoscopic Distal Gastrectomy VS Pylorus-Preserving Gastrectomy for Early Gastric Cancer in the Middle Stomach
Comparative Study on the Efficacy of Totally Laparoscopic Distal Gastrectomy and Pylorus-Preserving Gastrectomy for Early Gastric Cancer in the Middle Stomach
Source: ClinicalTrials.gov · Last updated 14 May 2025
Brief summary (registry, in English)
With the development of laparoscopic technology, the surgical treatment of early gastric cancer (EGC) has shifted towards minimally invasive, precise, and function-preserving strategies. Totally laparoscopic distal gastrectomy (TLDG) and totally laparoscopic pylorus-preserving gastrectomy (TLPPG) are minimally invasive procedures. However, there is a lack of systematic evidence to directly compare their efficacies. This study focuses on two fully laparoscopic techniques, TLDG and TLPPG, to address two key objectives: (1) whether TLPPG can avoid the long-term functional sequelae of TLDG while ensuring oncological safety, including complications (delayed gastric emptying, reflux, and dumping syndrome), postoperative quality of life (assessed via the PGSAS-37 scale), and survival outcomes; and (2) the balance between complications and survival in function-preserving surgery. The findings aim to provide critical technical parameters for individualized surgical decision-making in EGC.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 95 (actual)
- First submitted
- 26 Apr 2025
- Start date
- 1 Jan 2020
- Primary completion date
- 1 Mar 2025
- Lead sponsor
- Changzhi Medical College
- Diseases
- Gastric and esophageal cancer
- NCT number
- NCT06970327
What you commit to
- Study type: Observational
- Participants enrolled: 95
- From 1 Jan 2020 to the primary completion date, 1 Mar 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Concurrent malignant tumors, ascites, edema, or pleural effusion;
Other illness
- Severe anemia, coagulation disorders, or gastric outlet obstruction;
- History of gastric or upper abdominal surgery;
Other
- Gastric ulcers, polyps, or intestinal metaplasia.
Who the study is looking for
- Preoperative diagnosis of early gastric adenocarcinoma (invasion limited to the mucosa or submucosa) confirmed by tissue biopsy, abdominal enhanced CT, and endoscopic ultrasound;
- Tumor located in the gastric body or distal stomach, \>4 cm from the pylorus;
- Ineligible for endoscopic mucosal dissection or elected for surgical treatment by family;
- Complete clinical and pathological data.
Age in the registry: 18 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| HeJi hospital affiliated ChangZhi medical college Coordinator of this site? Confirm its status | Changzhi | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.