NCT06972472Active, not recruitingPhase 3
A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes
A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes
Source: ClinicalTrials.gov · Last updated 20 Apr 2026
Brief summary (registry, in English)
The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes. This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 600 (estimated)
- First submitted
- 7 May 2025
- Start date
- 19 May 2025
- Primary completion date
- Aug 2027
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity, Type 2 diabetes
- NCT number
- NCT06972472
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 600
- From 19 May 2025 to the primary completion date, Aug 2027
- 80 sites in 7 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have an unstable body weight within 90 days prior to screening
- Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening
- Are taking other medications or alternative remedies to manage weight loss
Other illness
- Have type 1 diabetes
- Have acute or chronic hepatitis or pancreatitis
Who the study is looking for
- Have body mass index (BMI) ≥25 kilograms per square meter (kg/m2) at screening
- Have type 2 diabetes
- Have hemoglobin A1c (HbA1c) ≥7% and ≤10% at screening
- Have a history of at least one unsuccessful dietary effort to lose body weight
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (80)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Centro Médico Viamonte Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| CIPREC Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| CARE - Centro de Alergia y Enfermedades Respiratorias Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Instituto Centenario Coordinator of this site? Confirm its status | CABA | Argentina | Unknown status |
| Instituto Médico Catamarca IMEC Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Centro de Diagnóstico y Rehabilitación (CEDIR) Coordinator of this site? Confirm its status | Santa Fe | Argentina | Unknown status |
| Xuanwu Hospital, Capital Medical University Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Peking University Third Hospital Coordinator of this site? Confirm its status | Beijing | China | Unknown status |
| Sichuan Provincial People's Hospital Coordinator of this site? Confirm its status | Chengdu | China | Unknown status |
| The Second Affiliated Hospital Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
| Zhujiang Hospital Coordinator of this site? Confirm its status | Guangzhou | China | Unknown status |
| The Fourth Affiliated Hospital of Harbin Medical University Coordinator of this site? Confirm its status | Harbin | China | Unknown status |
| The Second People's Hospital of Hefei Coordinator of this site? Confirm its status | Hefei | China | Unknown status |
| Jinan Central Hospital Coordinator of this site? Confirm its status | Jinan | China | Unknown status |
| The First Affiliated Hospital of Henan University of Science &Technology Coordinator of this site? Confirm its status | Luoyang Shi | China | Unknown status |
| The Second Affiliated Hospital of Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| Zhongda Hospital Southeast University Coordinator of this site? Confirm its status | Nanjing | China | Unknown status |
| The Second Hospital of Tianjin Medical University Coordinator of this site? Confirm its status | Tianjin | China | Unknown status |
| MUDr. Alena Vachova Coordinator of this site? Confirm its status | České Budějovice | Czechia | Unknown status |
| Nemocnice Cesky Krumlov Coordinator of this site? Confirm its status | Český Krumlov | Czechia | Unknown status |
| Donmed s.r.o. Coordinator of this site? Confirm its status | Ostrava | Czechia | Unknown status |
| Milan Kvapil s.r.o., Diabetologicka ambulance Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| Medical Plus Coordinator of this site? Confirm its status | Uherské Hradiště | Czechia | Unknown status |
| Medizentrum Essen Borbeck Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| InnoDiab Forschung Gmbh Coordinator of this site? Confirm its status | Essen | Germany | Unknown status |
| Diabetes Zentrum Wilhelmsburg Coordinator of this site? Confirm its status | Hamburg | Germany | Unknown status |
| AmBeNet GmbH Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut Coordinator of this site? Confirm its status | Leipzig | Germany | Unknown status |
| Medicover Neuroendokrinologie Coordinator of this site? Confirm its status | Munich | Germany | Unknown status |
| RED-Institut GmbH Coordinator of this site? Confirm its status | Oldenburg | Germany | Unknown status |
| Hasegawa Medicine Clinic Coordinator of this site? Confirm its status | Chitose | Japan | Unknown status |
| Fukuwa Clinic Coordinator of this site? Confirm its status | Chūōku | Japan | Unknown status |
| Tokyo-Eki Center-building Clinic Coordinator of this site? Confirm its status | Chūōku | Japan | Unknown status |
| The Institute of Medical Science, Asahi Life Foundation Coordinator of this site? Confirm its status | Chūōku | Japan | Unknown status |
| Tokuyama Clinic Coordinator of this site? Confirm its status | Mihama-ku,Chiba City | Japan | Unknown status |
| Medical Corporation Heishinkai ToCROM Clinic Coordinator of this site? Confirm its status | Shinjuku-ku | Japan | Unknown status |
| Medical Corporation Heishinkai OCROM Clinic Coordinator of this site? Confirm its status | Suita-shi | Japan | Unknown status |
| Olive Takamatsu Medical Clinic Coordinator of this site? Confirm its status | Takamatsu | Japan | Unknown status |
| Shimokitazawa Tomo Clinic Coordinator of this site? Confirm its status | Tokyo | Japan | Unknown status |
| Tsuchiura Medical & Health Care Center Coordinator of this site? Confirm its status | Tsuchiura | Japan | Unknown status |
| Noritake Clinic Coordinator of this site? Confirm its status | Ushiku | Japan | Unknown status |
| Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic Coordinator of this site? Confirm its status | Yamato-shi | Japan | Unknown status |
| Yokohama Minoru Clinic Coordinator of this site? Confirm its status | Yokohama | Japan | Unknown status |
| Puerto Rico Health and Wellness Institute Coordinator of this site? Confirm its status | Dorado | Puerto Rico | Unknown status |
| Isis Clinical Research Center Coordinator of this site? Confirm its status | Guaynabo | Puerto Rico | Unknown status |
| Great Lakes Research Group, Inc. Coordinator of this site? Confirm its status | Bay City | United States | Unknown status |
| Javara - Nevada Health Centers - Carson City Coordinator of this site? Confirm its status | Carson City | United States | Unknown status |
| University of North Carolina Medical Center Coordinator of this site? Confirm its status | Chapel Hill | United States | Unknown status |
| Javara - Tryon Medical Partners Coordinator of this site? Confirm its status | Charlotte | United States | Unknown status |
| The Corvallis Clinic, P.C. Coordinator of this site? Confirm its status | Corvallis | United States | Unknown status |
| Velocity Clinical Research, Dallas Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Accel Research Sites - NeuroStudies Clinical Research Unit Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Care Access - Decatur Coordinator of this site? Confirm its status | Decatur | United States | Unknown status |
| Accel Research Sites - DeLand Clinical Research Unit Coordinator of this site? Confirm its status | DeLand | United States | Unknown status |
| Care Access - Fayetteville Coordinator of this site? Confirm its status | Fayetteville | United States | Unknown status |
| Innovation Medical Research Center - Fort Lauderdale Coordinator of this site? Confirm its status | Fort Lauderdale | United States | Unknown status |
| Indago Research & Health Center, Inc Coordinator of this site? Confirm its status | Hialeah | United States | Unknown status |
| Encore Medical Research Coordinator of this site? Confirm its status | Hollywood | United States | Unknown status |
| Biopharma Informatic, LLC Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| Activian Clinical Research Coordinator of this site? Confirm its status | Kingwood | United States | Unknown status |
| The Machuca Foundation Coordinator of this site? Confirm its status | Las Vegas | United States | Unknown status |
| Solaris Clinical Research Coordinator of this site? Confirm its status | Meridian | United States | Unknown status |
| Texas Valley Clinical Research (TVCR) - Mission Coordinator of this site? Confirm its status | Mission | United States | Unknown status |
| Boeson Research MSO Coordinator of this site? Confirm its status | Missoula | United States | Unknown status |
| Care Access - New Iberia Coordinator of this site? Confirm its status | New Iberia | United States | Unknown status |
| West Orange Endocrinology P.A. Coordinator of this site? Confirm its status | Ocoee | United States | Unknown status |
| Clinical Research of Philadelphia Coordinator of this site? Confirm its status | Philadelphia | United States | Unknown status |
| Endocrine and Metabolic Consultants Coordinator of this site? Confirm its status | Rockville | United States | Unknown status |
| Norcal Endocrinology & Internal Medicine Coordinator of this site? Confirm its status | San Ramon | United States | Unknown status |
| Southern California Clinical Research Coordinator of this site? Confirm its status | Santa Ana | United States | Unknown status |
| Javara - Privia Medical Group Georgia - Savannah Coordinator of this site? Confirm its status | Savannah | United States | Unknown status |
| Consano Clinical Research, LLC Coordinator of this site? Confirm its status | Shavano Park | United States | Unknown status |
| Javara - Privia Medical Group - Silver Spring Coordinator of this site? Confirm its status | Silver Spring | United States | Unknown status |
| Frontier Clinical Research, LLC Coordinator of this site? Confirm its status | Smithfield | United States | Unknown status |
| Clinical Research Institute of Arizona (CRI) - Sun City West Coordinator of this site? Confirm its status | Sun City West | United States | Unknown status |
| Care Access - Tampa Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Care Access - Thousand Oaks Coordinator of this site? Confirm its status | Thousand Oaks | United States | Unknown status |
| Novak Clinical Research - Tucson - North La Cholla Boulevard Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| Conquest Research Coordinator of this site? Confirm its status | Winter Park | United States | Unknown status |
| North Georgia Clinical Research Coordinator of this site? Confirm its status | Woodstock | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.