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NCT06972472Active, not recruitingPhase 3

A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Type 2 Diabetes

A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes

Source: ClinicalTrials.gov · Last updated 20 Apr 2026

Brief summary (registry, in English)

The main purpose of this study is to see how orforglipron, compared with placebo, helps improve glycemic control in participants with obesity or with overweight and type 2 diabetes. This trial is part of the master protocol study J2A-MC-GZPO (NCT06993792). Participation in the study will last about 18 months.

Status (registry)
Active, not recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
600 (estimated)
First submitted
7 May 2025
Start date
19 May 2025
Primary completion date
Aug 2027
Lead sponsor
Eli Lilly and Company
NCT number
NCT06972472

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 600
  • From 19 May 2025 to the primary completion date, Aug 2027
  • 80 sites in 7 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Have an unstable body weight within 90 days prior to screening
  • Have New York Heart Association functional classification IV congestive heart failure or an acute cardiovascular condition within 90 days prior to screening
  • Are taking other medications or alternative remedies to manage weight loss

Other illness

  • Have type 1 diabetes
  • Have acute or chronic hepatitis or pancreatitis

Who the study is looking for

  • Have body mass index (BMI) ≥25 kilograms per square meter (kg/m2) at screening
  • Have type 2 diabetes
  • Have hemoglobin A1c (HbA1c) ≥7% and ≤10% at screening
  • Have a history of at least one unsuccessful dietary effort to lose body weight

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (80)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Centro Médico Viamonte
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Buenos AiresArgentinaUnknown status
CIPREC
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Buenos AiresArgentinaUnknown status
CARE - Centro de Alergia y Enfermedades Respiratorias
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Buenos AiresArgentinaUnknown status
Instituto Centenario
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CABAArgentinaUnknown status
Instituto Médico Catamarca IMEC
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RosarioArgentinaUnknown status
Centro de Diagnóstico y Rehabilitación (CEDIR)
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Santa FeArgentinaUnknown status
Xuanwu Hospital, Capital Medical University
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BeijingChinaUnknown status
Peking University Third Hospital
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BeijingChinaUnknown status
Sichuan Provincial People's Hospital
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ChengduChinaUnknown status
The Second Affiliated Hospital Chongqing Medical University
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ChongqingChinaUnknown status
Zhujiang Hospital
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GuangzhouChinaUnknown status
The Fourth Affiliated Hospital of Harbin Medical University
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HarbinChinaUnknown status
The Second People's Hospital of Hefei
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HefeiChinaUnknown status
Jinan Central Hospital
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JinanChinaUnknown status
The First Affiliated Hospital of Henan University of Science &Technology
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Luoyang ShiChinaUnknown status
The Second Affiliated Hospital of Nanjing Medical University
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NanjingChinaUnknown status
Zhongda Hospital Southeast University
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NanjingChinaUnknown status
The Second Hospital of Tianjin Medical University
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TianjinChinaUnknown status
MUDr. Alena Vachova
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České BudějoviceCzechiaUnknown status
Nemocnice Cesky Krumlov
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Český KrumlovCzechiaUnknown status
Donmed s.r.o.
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OstravaCzechiaUnknown status
Milan Kvapil s.r.o., Diabetologicka ambulance
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PragueCzechiaUnknown status
Medical Plus
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Uherské HradištěCzechiaUnknown status
Medizentrum Essen Borbeck
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EssenGermanyUnknown status
InnoDiab Forschung Gmbh
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EssenGermanyUnknown status
Diabetes Zentrum Wilhelmsburg
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HamburgGermanyUnknown status
AmBeNet GmbH
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LeipzigGermanyUnknown status
Gemeinschaftspraxis Dr. Taeschner/Dr. Bonigut
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LeipzigGermanyUnknown status
Medicover Neuroendokrinologie
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MunichGermanyUnknown status
RED-Institut GmbH
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OldenburgGermanyUnknown status
Hasegawa Medicine Clinic
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ChitoseJapanUnknown status
Fukuwa Clinic
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ChūōkuJapanUnknown status
Tokyo-Eki Center-building Clinic
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ChūōkuJapanUnknown status
The Institute of Medical Science, Asahi Life Foundation
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ChūōkuJapanUnknown status
Tokuyama Clinic
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Mihama-ku,Chiba CityJapanUnknown status
Medical Corporation Heishinkai ToCROM Clinic
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Shinjuku-kuJapanUnknown status
Medical Corporation Heishinkai OCROM Clinic
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Suita-shiJapanUnknown status
Olive Takamatsu Medical Clinic
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TakamatsuJapanUnknown status
Shimokitazawa Tomo Clinic
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TokyoJapanUnknown status
Tsuchiura Medical & Health Care Center
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TsuchiuraJapanUnknown status
Noritake Clinic
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UshikuJapanUnknown status
Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic
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Yamato-shiJapanUnknown status
Yokohama Minoru Clinic
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YokohamaJapanUnknown status
Puerto Rico Health and Wellness Institute
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DoradoPuerto RicoUnknown status
Isis Clinical Research Center
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GuaynaboPuerto RicoUnknown status
Great Lakes Research Group, Inc.
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Bay CityUnited StatesUnknown status
Javara - Nevada Health Centers - Carson City
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Carson CityUnited StatesUnknown status
University of North Carolina Medical Center
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Chapel HillUnited StatesUnknown status
Javara - Tryon Medical Partners
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CharlotteUnited StatesUnknown status
The Corvallis Clinic, P.C.
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CorvallisUnited StatesUnknown status
Velocity Clinical Research, Dallas
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DallasUnited StatesUnknown status
Accel Research Sites - NeuroStudies Clinical Research Unit
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DecaturUnited StatesUnknown status
Care Access - Decatur
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DecaturUnited StatesUnknown status
Accel Research Sites - DeLand Clinical Research Unit
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DeLandUnited StatesUnknown status
Care Access - Fayetteville
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FayettevilleUnited StatesUnknown status
Innovation Medical Research Center - Fort Lauderdale
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Fort LauderdaleUnited StatesUnknown status
Indago Research & Health Center, Inc
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HialeahUnited StatesUnknown status
Encore Medical Research
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HollywoodUnited StatesUnknown status
Biopharma Informatic, LLC
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HoustonUnited StatesUnknown status
Activian Clinical Research
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KingwoodUnited StatesUnknown status
The Machuca Foundation
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Las VegasUnited StatesUnknown status
Solaris Clinical Research
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MeridianUnited StatesUnknown status
Texas Valley Clinical Research (TVCR) - Mission
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MissionUnited StatesUnknown status
Boeson Research MSO
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MissoulaUnited StatesUnknown status
Care Access - New Iberia
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New IberiaUnited StatesUnknown status
West Orange Endocrinology P.A.
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OcoeeUnited StatesUnknown status
Clinical Research of Philadelphia
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PhiladelphiaUnited StatesUnknown status
Endocrine and Metabolic Consultants
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RockvilleUnited StatesUnknown status
Norcal Endocrinology & Internal Medicine
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San RamonUnited StatesUnknown status
Southern California Clinical Research
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Santa AnaUnited StatesUnknown status
Javara - Privia Medical Group Georgia - Savannah
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SavannahUnited StatesUnknown status
Consano Clinical Research, LLC
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Shavano ParkUnited StatesUnknown status
Javara - Privia Medical Group - Silver Spring
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Silver SpringUnited StatesUnknown status
Frontier Clinical Research, LLC
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SmithfieldUnited StatesUnknown status
Clinical Research Institute of Arizona (CRI) - Sun City West
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Sun City WestUnited StatesUnknown status
Care Access - Tampa
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TampaUnited StatesUnknown status
Care Access - Thousand Oaks
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Thousand OaksUnited StatesUnknown status
Novak Clinical Research - Tucson - North La Cholla Boulevard
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TucsonUnited StatesUnknown status
Conquest Research
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Winter ParkUnited StatesUnknown status
North Georgia Clinical Research
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WoodstockUnited StatesUnknown status

This page is information, not medical advice. Discuss any trial with your doctor.