Exploratory Study of the Microbiome of Upper Gastrointestinal in the Pathogenesis of Multiple Primary Lung Cancer

Prior treatment

• Preoperative examination of patients who cannot tolerate surgical resection
• Patients who received antibiotics within 1 week before surgery E) Resected multiple pulmonary nodules with pathologically proven lung cancer of less than 2 patients

Other illness

• severe heart, liver, brain, kidney and other important organ diseases and bone marrow hematopoietic dysfunction;
• Multiple nodules resected were confirmed to be metastases, not primary lung cancer

Age

• under 18 years of age (excluding 18 years of age, male or female) or unwilling to sign informed consent;

• At least 18 years of age (including 18 years of age, male or female) and voluntarily signed informed consent;
• Chest CT imaging showed at least 2 pulmonary nodules with a diameter of less than 3cm in ipsilateral lung, and imaging diagnosis of highly suspicious multiple primary lung cancer
• No surgical contraindication, surgical resection is feasible, and postoperative pathology is diagnosed as multiple primary lung cancer according to Martini and Melamed criteria and gene testing
• The amount of at least 2 or more tissues removed from multiple pulmonary nodules must meet the requirements of pathological diagnosis, molecular detection and microflora detection