NCT06973603Not yet recruiting
Exposure to Persistent Organic Pollutants and Severity of Endometriosis in the ComPaRe-Endometriosis Cohort
Source: ClinicalTrials.gov · Last updated 16 Sept 2026
Brief summary (registry, in English)
Endometriosis is a chronic inflammatory disease affecting \~10% of women of childbearing age. It is characterized by the presence of endometrial-like tissue outside the uterus, causing lesions and adhesions between the organs, and is often accompanied by intense pain and sometimes infertility. The four-stage classification based on the severity of lesions does not always reflect the severity of symptoms. Adenomyosis, a similar pathology, is often present in the same patients, although it is now considered distinct from endometriosis. Diagnosis usually takes a long time, with an average delay of 7 years. The cause of the disease remains unknown, but hormonal, genetic and environmental factors, such as exposure to endocrine disruptors, are suspected. Persistent organic pollutants (POPs), such as dioxins and PCBs, may influence the risk and severity of the disease. Although experimental studies suggest a link between these substances and the progression of endometriosis, epidemiological research on the subject is still limited. The central hypothesis of the POPENDO project is that higher concentrations of persistent organic pollutants (POPs) are associated with increased severity of endometriosis. The aim of the study is to explore the associations between serum levels of four families of POPs (PCBs, organochlorine pesticides, PFAS and BFR) and endometriosis.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 650 (estimated)
- First submitted
- 7 May 2025
- Start date
- Dec 2026
- Primary completion date
- Dec 2026
- Lead sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
- Diseases
- Endometriosis
- NCT number
- NCT06973603
What you commit to
- Study type: Observational
- Planned participants: 650
- From Dec 2026 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Hemophilia/coagulation disorders/anticoagulant use
- People with HIV, HBV or HCV will not be included in this study due to the risk of BSE (Blood Exposure Accident).
- People suffering from any of the following diseases:
- Cancer
- Morbid obesity (BMI\>40)
- Non-alcoholic steatohepatitis (NASH)
Other
- \- People with contraindications to blood sampling will not be included in this research:
- Known severe anemia
- Based on factors that may disrupt lipid dynamics and lipid pollutants, the following individuals will not be included:
- Pregnant and breast-feeding women
- Persons under court protection/guardianship/guardianship will not be able to participate in this research.
Who the study is looking for
- ComPaRe participants ⩾ 18 years old. All ComPaRe participants are at least 18 years of age, so our research participants will all be adults.
- Having declared in ComPaRe that they had endometriosis
- Living in the Ile-de-France region (departments 75, 77, 78, 91, 92, 93, 94 or 95);
- Have given electronic consent stating: "By checking this box, I agree to be solicited for research outside ComPaRe"; This criterion is collected at the time of ComPaRe registration, when consent is collected. Participants can withdraw this consent at any time on their secure personal online account on the ComPaRe platform.
- Aged ≤ 45 years to avoid including premenopausal or menopausal women;
- In possession of MRI images used to diagnose their endometriosis (CD-ROM) that are no more than 5 years old;
- Enrolled in or benefiting from a social security scheme.
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hôpital Paris Saint Joseph Coordinator of this site? Confirm its status | Paris | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.