NCT06977269Recruiting
Safety and Tolerability of Low Motoneuron Stimulation Via Transcranial Magnetic Stimulation in Spinal Muscular Atrophy
Source: ClinicalTrials.gov · Last updated 18 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
There is a general physiological rule that any organ or system needs some minimal amount of activity to prevent its atrophy or degeneration. Although the relevance of that rule to exercises in neuromuscular patients and for SMA in particular is not definitely proven, clinical observations seem to support this assumption. Also there are several experimental studies which provide additional support for utility of exercise for SMA. However, making regular exercises may be very challenging with SMA not only due to physical limitations, but due to psychological either. While being considered as safe and well tolerated intervention, TMS is able to mimic effects of real physical exercises, at least at the level of low motoneuron, it also provides several advantages. For example, possibility to exercise non-collaborative infants, minimization of psychological motivation impact in adults and/or ability to involve very weak muscle groups.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 20 (estimated)
- First submitted
- 9 May 2025
- Start date
- 19 May 2025
- Primary completion date
- Dec 2025
- Lead sponsor
- Charitable Foundation Children with Spinal Muscular Atrophy
- Diseases
- Spinal muscular atrophy
- NCT number
- NCT06977269
What you commit to
- Study type: Interventional
- Planned participants: 20
- From 19 May 2025 to the primary completion date, Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Subject has severe joint contractures that would affect ability to perform study measures, determined by the study physician.
- Subject has a deconditioned respiratory system, per the discretion of the physician investigator.
- Subject has behavioral or cognitive problems that preclude participation in the study, in the opinion of the investigator.
Who the study is looking for
- Subject has a diagnosis of 5q-autosomal recessive SMA confirmed by DNA test.
- Informed consent.
- A minimum score of 1 for Entry Item "A" of the Revised Upper Limb Module (RULM) scale for SMA: "Can use hands to hold pencil or pick up a coin/token or drive a powered chair, use phone key pad"
Age in the registry: 12 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| P.V. Voloshyn Institute of Neurology, Psychiatry and Narcology of the National Academy of Medical Sciences of Ukraine Coordinator of this site? Confirm its status | Kharkiv | Ukraine | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.