NCT06978881Enrolling by invitation
Magnetoencephalography in Psychosis Program
Temporal Regularity of Neural Activity and Its Relationship to Psychotic Symptoms
Source: ClinicalTrials.gov · Last updated 18 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This research involves the examination of speech, thinking patterns and symptoms and recordings from brain's activity in patients with schizophrenia. The reserchers are investigating if the electrical waves (recorded indirectly using the resulting magnetic field around our head) are disrupted in psychosis, especially in the language related problems seen in this disorder. To examine language, participants will be asked to complete a speech tasks using the DISCOURSE speech elicitation script in which they will be requested to share their thoughts. For this purpose, the participants will be shown some pictures and asked to describe what they see, discuss a significant event from their life and tell a story in their own words. The description of the pictures and other responses to the tasks will be audio-recorded for later transcription into a written format. The researches will examine the brain regions using Magnetoencephalography (MEG) and Magnetic Resonance Imaging (MRI). MEG and MRI are both non-invasive functional brain imaging technologies. MRI collects structural information and creates images of the brain while MEG collects magnetic activity from neurons, visualized as brain waves. The MRI machine uses a large magnet to help create images while MEG captures the fluctuations in the small magnetic fields resulting from brain's activity. Participants will also undergo a clinical and neurocognitive assessments. This project design involves 50 individuals who will take part in the study; 25 affected and 25 healthy volunteers aged 18 to 50 years.
- Status (registry)
- Enrolling by invitation
- Study type
- Observational
- Enrollment
- 50 (estimated)
- First submitted
- 13 Jan 2025
- Start date
- 8 May 2024
- Primary completion date
- Nov 2025
- Lead sponsor
- Douglas Mental Health University Institute
- Diseases
- Schizophrenia
- NCT number
- NCT06978881
What you commit to
- Study type: Observational
- Planned participants: 50
- From 8 May 2024 to the primary completion date, Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History of head trauma, major neurological disorders (e.g., epilepsy), somatic disorders with neurological complaints (e.g., multiple sclerosis), or intellectual disabilities.
- Diagnosis of substance use disorder (current or within the last year) as per DSM-5.
- History of head trauma, major neurological disorders (e.g., epilepsy), somatic disorders with neurological complaints (e.g., multiple sclerosis), or intellectual disabilities.
- Diagnosis of substance use disorder (current or within the last year) as per DSM-5.
- Personal or family history of psychotic disorder.
Other
- Inability to speak English or French.
- Unsuitable for MRI due to safety concerns (e.g., metal in the body, pregnancy, tinnitus).
- Healthy Controls
- Inability to speak English or French.
- Unsuitable for MRI due to safety concerns (e.g., metal in the body, pregnancy, tinnitus).
Who the study is looking for
- Clinical diagnosis of schizophrenia as per DSM-5 criteria.
- Aged between 18 and 50 years.
- In a stable phase of the illness (no change in Global Functioning \> 10 units within 1 month before the MEG scan assessed using the Global Assessment of Functioning Scale).
- Healthy volunteers aged between 18 and 50 years.
- Matched to patients for age (within 2 years), sex, and parental occupational status (rated by NS-SEC).
Criteria the registry did not label
- Patients:
Age in the registry: 18 years to 50 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Douglas Mental Health University Institute Coordinator of this site? Confirm its status | Montreal | Canada | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.