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NCT06979336RecruitingPhase 2

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)

A Phase IIb, Multicenter, Double-blind, Placebo-controlled Induction Study With an Active Treatment Extension to Assess the Efficacy, Safety, and Pharmacokinetics of RO7837195 in Patients With Moderately to Severely Active Ulcerative Colitis

Source: ClinicalTrials.gov · Last updated 27 Oct 2026

Brief summary (registry, in English)

The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.

Status (registry)
Recruiting
Phase (registry)
Phase 2
Study type
Interventional
Enrollment
224 (estimated)
First submitted
15 May 2025
Start date
29 Sept 2025
Primary completion date
25 Aug 2027
Lead sponsor
Genentech, Inc.
NCT number
NCT06979336
EU CT number
2025-520690-39-00

What you commit to

  • Study type: Interventional · Phase 2
  • Planned participants: 224
  • From 29 Sept 2025 to the primary completion date, 25 Aug 2027
  • 118 sites in 15 countries
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Prior treatment

  • Prior extensive colonic resection, subtotal or total colectomy, or planned surgery for UC
  • Treatment with an advanced therapy targeted at tumor necrosis factor-like cytokine 1A (TL1a)
  • Inadequate response, loss of response, or intolerance to treatment of UC with an advanced therapy targeted at IL-12 and/or IL-23

Other illness

  • Diagnosis of Crohn's disease or indeterminate colitis

Who the study is looking for

  • Diagnosis of ulcerative colitis (UC) established at least 3 months
  • Moderately to severely active UC assessed by mMS
  • Inadequate response, loss of response, or intolerance to conventional or advanced therapies for UC

Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

Sites (118)

Sites in registry order. Pick your city on the disease page to sort them by distance.

SiteCityCountrySite status
Royal Prince Alfred Hospital
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CamperdownAustraliaRecruiting
Fiona Stanley Hospital
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MurdochAustraliaRecruiting
Royal Melbourne Hospital
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Parkville VICAustraliaRecruiting
Mater Misericordiae Limited
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South BrisbaneAustraliaRecruiting
Newdata Clinical Trials
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AracajuBrazilRecruiting
Hospital Felicio Rocho
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Belo HorizonteBrazilRecruiting
L2IP - Instituto de Pesquisas Clínicas Ltda
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BrasíliaBrazilRecruiting
Chronos Pesquisa Clínica
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BrasíliaBrazilRecruiting
Centro Digestivo de Curitiba
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CuritibaBrazilRecruiting
Associao Paranaense de Cultura APC
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CuritibaBrazilRecruiting
HUWC - UFC - Hospital Universitrio Walter Cantdio - Universidade Federal do Cear
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FortalezaBrazilRecruiting
CECIP - Centro de Estudos Clínicos do Interior Paulista
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JaBrazilRecruiting
Hospital de Clnicas de Porto Alegre
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Porto AlegreBrazilRecruiting
Hospital Ernesto Dornelles
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Porto AlegreBrazilRecruiting
Hospital Gloria DOr - Hospitais Integrados da Gavea S/A
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Rio de JaneiroBrazilRecruiting
Pesquisare Saude
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Santo AndréBrazilRecruiting
Kaiser Clinica
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São Jose Do Rio PretoBrazilRecruiting
Instituto de Assistencia Medica ao Servidor Publico Estudo Estadual
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São PauloBrazilRecruiting
BR Trials - Ensaios Clnicos e Consultoria
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São PauloBrazilRecruiting
CPQuali Pesquisa Clinica Ltda
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So PauloBrazilRecruiting
London Digestive Disease Institute
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LondonCanadaRecruiting
Hopital Maisonneuve-Rosemont d/b/a CIUSSS de l'Est-de-l'le-de-Montral
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MontrealCanadaRecruiting
Clinique IMD
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MontrealCanadaRecruiting
Binzhou Medical University Hospital
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BinzhouChinaRecruiting
The First Hospital of Jilin University
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ChangchunChinaRecruiting
Sichuan Provincial People's Hospital
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ChengduChinaRecruiting
The First Affiliated Hospital of Fujian Medical University
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FuzhouChinaRecruiting
The second Affiliated Hospital of Guangzhou Medical University
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GuangzhouChinaRecruiting
The Sixth Affiliated Hospital of Sun Yat-sen University
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GuangzhouChinaRecruiting
Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University
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HangzhouChinaRecruiting
Huizhou Municipal Central Hospital
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HuizhouChinaRecruiting
The First Affiliated Hospital of Ningbo University
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NingboChinaRecruiting
Renmin Hospital of Wuhan University
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WuhanChinaRecruiting
Zhongshan Hospital Xiamen University
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XiamenChinaRecruiting
The Second Affiliated Hospital of Zhengzhou University
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ZhengzhouChinaRecruiting
PreventaMed, s.r.o.
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OlomoucCzechiaRecruiting
Goethe University Frankfurt
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Frankfurt Am MainGermanyRecruiting
Universitaetsklinikum Regensburg AöR
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RegensburgGermanyRecruiting
University Hospital Of Clermont-Ferrand
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Clermont-FerrandFranceRecruiting
Centre Medico Chirurgical Ambroise Pare Hartmann
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Neuilly-Sur-SeineFranceRecruiting
Hospices Civils de Lyon
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Pierre-BéniteFranceRecruiting
Centre Hospitalier Universitaire de Saint Etienne
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Saint-Priest-en-JarezFranceRecruiting
Addenbrook'es Hospital
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CambridgeUnited KingdomRecruiting
Royal Liverpool University Hospital
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LiverpoolUnited KingdomRecruiting
Guy's Hospital
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LondonUnited KingdomRecruiting
King's College Hospital
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LondonUnited KingdomRecruiting
John Radcliffe Hospital
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OxfordUnited KingdomRecruiting
Asian Institute Of Gastroenterology
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HyderabadIndiaRecruiting
S.R.Kalla Memorial Gastro & General Hospital
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JaipurIndiaRecruiting
Institute of Post-Graduate Medical Education and Research
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KolkataIndiaRecruiting
Kingsway Hospital
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NagpurIndiaRecruiting
Shree Giriraj Multispeciality Hospital
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RajkotIndiaRecruiting
Fondazione Poliambulanza
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BresciaItalyRecruiting
Ospedale San Raffaele S.r.l.
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MilanItalyRecruiting
IRCCS Ospedale Sacro Cuore Don Calabria
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NegrarItalyRecruiting
Fondazione IRCCS Policlinico San Matteo
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PaviaItalyRecruiting
Azienda Socio Sanitaria Territoriale Rhodense
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RhoItalyRecruiting
Fondazione Policlinico Universitario Agostino Gemelli IRCCS
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RomeItalyRecruiting
Humanitas Mirasole S.p.A.
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RozzanoItalyRecruiting
Policlinico San Donato S.p.A.
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San Donato MilaneseItalyRecruiting
Azienda Ospedaliera Ordine Mauriziano di Torino
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TurinItalyRecruiting
Shinseikai Sai Gastroenterology, Proctology
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Fujidera-shiJapanRecruiting
Fukuoka University Hospital
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FukuokaJapanRecruiting
NHO Fukuyama Medical Center
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Fukuyama-shiJapanRecruiting
NHO Kanazawa Medical Center
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KanazawaJapanRecruiting
Kokikai Tsujinaka Hospital Kashiwanoha
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Kashiwa-shiJapanRecruiting
Kojunkai Daido Clinic
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NagoyaJapanRecruiting
NHO Osaka National Hospital
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OsakaJapanRecruiting
Saga University Hospital
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SagaJapanRecruiting
Takamatsu Red Cross Hospital
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TakamatsuJapanRecruiting
Inje University Haeundae Paik Hospital
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BusanSouth KoreaRecruiting
The Catholic University of Korea, Daejeon ST.Mary's Hospital
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DaejeonSouth KoreaRecruiting
Chosun University Hospital
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GwangjuSouth KoreaRecruiting
Samsung Medical Center
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SeoulSouth KoreaRecruiting
The Catholic University of Korea, Eunpyeong St. Mary's Hospital
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SeoulSouth KoreaRecruiting
Chung ang University Hospital
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SeoulSouth KoreaRecruiting
Asan Medical Center
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SeoulSouth KoreaRecruiting
Kangbuk Samsung Hospital
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SeoulSouth KoreaRecruiting
Yonsei University Wonju Severance Christian Hospital
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WŏnjuSouth KoreaRecruiting
Clinica de Investigacion en Reumatologia y Obesidad S. C.
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GuadalajaraMexicoRecruiting
Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan (
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MéridaMexicoRecruiting
Centro de Alta Especialidad en Reumatologia e Investigación del Potosi,S.C
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San Luis Potosí CityMexicoRecruiting
Centro Medico Clinico Quirurgico Especializado en Investigacion
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Tlajomulco de ZúñigaMexicoRecruiting
FAICIC S. de R.L. de C.V.
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VeracruzMexicoRecruiting
Manermed Sp. z o.o.
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BydgoszczPolandRecruiting
Osrodek Badan Klinicznych Clinsante S.C. Ewa Galczak-Nowak Malgorzata
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BydgoszczPolandRecruiting
Centrum Medyczne LukaMed Joanna Łuka
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ChojnicePolandRecruiting
Centrum Medyczne Plejady Magdalena Celinska Loewenhoff Michal Zolnowski sp.k.
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CracowPolandRecruiting
Centrum Medyczne Clw-Med Aneta Cichomska I Joanna Luka-Wendrowska Sp. j.
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GrudziadzPolandRecruiting
Vita Longa Sp. Z o.o.
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KatowicePolandRecruiting
MZ Badania Slowik Zymla Sp.j.
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KnurówPolandRecruiting
Allmedica Badania Kliniczne Sp z o.o. Sp K.
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Nowy TargPolandRecruiting
Twoja Przychodnia Opolskie Centrum Medyczne
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OpolePolandRecruiting
Clinical Research Center Sp z o o Medic R Sp k
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PoznanPolandRecruiting
Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o.o.
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PoznanPolandRecruiting
Solumed Centrum Medyczne Sp. z o.o.
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PoznanPolandRecruiting
Termedia Sp. z o.o.
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PoznanPolandRecruiting
EMC Instytut Medyczny S.A.
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PoznanPolandRecruiting
Velocity Skierniewice Sp. z o.o.
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SkierniewicePolandRecruiting
Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.
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SzczecinPolandRecruiting
Wsd Medi Clinical Sp. z o.o.
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WarsawPolandRecruiting
Medical Network Sp z o o
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WarsawPolandRecruiting
Eb Group Sp. z o.o.
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WarsawPolandRecruiting
Provita Poliklinika sp. z o.o
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WarsawPolandRecruiting
Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
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WarsawPolandRecruiting
Medon Clinical Research Sp. z o.o.
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WarsawPolandRecruiting
Vistamed & Vertigo Sp Z O O
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WroclawPolandRecruiting
Centrum Medyczne Oporow
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WroclawPolandRecruiting
Etg Zamosc Sp. z o.o.
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ZamośćPolandRecruiting
University of Chicago Medical Center
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ChicagoUnited StatesRecruiting
Peak Gastroenterology Associates
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Colorado SpringsUnited StatesRecruiting
Intercity Gastroenterology
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Fresh MeadowsUnited StatesRecruiting
Clinical Research of Osceola, LLC
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KissimmeeUnited StatesRecruiting
Gastro Care Institute
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LancasterUnited StatesRecruiting
Monroe Biomedical Research
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MonroeUnited StatesRecruiting
University of Rochester - PARENT
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RochesterUnited StatesRecruiting
University of Utah Hospitals & Clinics
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Salt Lake CityUnited StatesRecruiting
Medical Associates Research Group, Inc.
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San DiegoUnited StatesRecruiting

This page is information, not medical advice. Discuss any trial with your doctor.