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NCT06980545Not yet recruitingPhase 3

Total Neoadjuvant 6 Cycles of Chemotherapy Versus 3 Cycles in Partial Responder Patients Diagnosed With Epithelial Ovarian Cancer

Phase 3 Study to Evaluate the Role of Total Neoadjuvant Chemotherapy in Partial Responders of Locally Advanced Ovarian Cancer Cancers (NeoPAR Study)

Source: ClinicalTrials.gov · Last updated 20 May 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

neoadjuvant chemotherapy in stage III and IV ovarian cancer is given in 3-4 cycles with patients who R0 surgical resection is less likely to occur, in this study will assess total neoadjuvant chemotherapy 6 cycles then interval debulking surgery (experimental arm) versus 4 cycles then interval debulking surgery (control arm) in patients who achieve partial response or stationary disease by imaging after 3- 4 cycles of neoadjuvant chemotherapy, investigators'' primary end points will be event free survival, safety and tolerability and time to relapse, our secondary end points will be overall survival and surgical morbidity and mortality

Status (registry)
Not yet recruiting
Phase (registry)
Phase 3
Study type
Interventional
Enrollment
50 (estimated)
First submitted
15 Mar 2025
Start date
30 Jun 2025
Primary completion date
30 Apr 2026
Lead sponsor
Assiut University
NCT number
NCT06980545

What you commit to

  • Study type: Interventional · Phase 3
  • Planned participants: 50
  • From 30 Jun 2025 to the primary completion date, 30 Apr 2026
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Relapsed ovarian cancer

Other

  • patients ineligible for Platinum-based CTH
  • Patient not candidate for IDS
  • stage I, II OC
  • Patients progressed after 3 cycles
    • 7-Patients do not tolerate CTH

Who the study is looking for

  • \> 18 years of age
  • Recently diagnosed with stage III and IV OC
  • Patients eligible for Platinum-based CTH
  • Patients have PR or SD after 3-4 cycles of NACT

Age in the registry: 18 years to - · Sex: Female · Does not accept healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.