NCT06980623Active, not recruiting
Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
Source: ClinicalTrials.gov · Last updated 15 May 2026
Brief summary (registry, in English)
This cohort study aims to assess the comparative effectiveness of tirzepatide versus semaglutide with respect to cardiovascular events in patients with type 2 diabetes and heart failure with preserved ejection fraction.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 26000 (estimated)
- First submitted
- 12 May 2025
- Start date
- 1 Jan 2025
- Primary completion date
- 30 Nov 2025
- Lead sponsor
- Brigham and Women's Hospital
- Diseases
- Heart failure, Type 2 diabetes
- NCT number
- NCT06980623
What you commit to
- Study type: Observational
- Planned participants: 26000
- From 1 Jan 2025 to the primary completion date, 30 Nov 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous exposure to other GLP-1RA and pramlintide
Other illness
- Patients with type 1 diabetes mellitus, secondary or gestational diabetes
- History of diabetes related complications
- Patients with related chronic diseases.
- History of gastrointestinal conditions.
Age
- Patients with missing age or sex information
Other
- Patients with prescription dispensing for both tirzepatide and semaglutide on cohort entry date
Who the study is looking for
- Patients who are new users of tirzepatide or new users of semaglutide
- Patients with diagnosis of T2D and HFpEF, i.e., EF \>= 45%.
- Age \>= 18 years old
- Patients with continuous health plan enrollment before and including the treatment initiation date
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Brigham and Women's Hospital Coordinator of this site? Confirm its status | Boston | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.