NCT06982378Withdrawn
GLP-1 RA on Liver OMICS in MASLD
Effect of Glucagon-like Peptide -1 Receptor Agonist on Liver Tissue and Plasma Lipids in MASLD
Source: ClinicalTrials.gov · Last updated 13 Jul 2026
Reason given: no grant approved
Brief summary (registry, in English)
In patients with type II diabetes mellitus (T2DM) and obesity, an excess plasma-free fatty acid is found with an associated increased lipid accumulation in adipocytes and liver tissue. Lipid droplet accumulation in the hepatocytes is an initial step in the development of metabolic dysfunction associated steatotic liver disease (MASLD. Insulin resistance, which is associated with T2DM, mediates the inflammation of these lipids, resulting in the progression of MASLD to metabolic dysfunction associated steatotic hepatitis (MASH). Hence, in T2DM, obesity, and MASLD, changes in the lipid profile occur, and they are interrelated. In this study, we aim to assess improvement in the lipidomic, its associated metabolic changes and evaluate the co-regulated genes in the liver tissue among patients with MASLD with intervention with GLP-1 RA, which has shown to benefit T2DM and obesity.
- Status (registry)
- Withdrawn
- Study type
- Observational
- Enrollment
- 0 (actual)
- First submitted
- 13 May 2025
- Start date
- 1 Jul 2026
- Primary completion date
- 9 Jul 2026
- Lead sponsor
- Medical College of Wisconsin
- Diseases
- Fatty liver disease (MASLD/MASH), Obesity
- NCT number
- NCT06982378
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- on immunosuppression, liver or kidney transplant
Other illness
- unable to have a liver biopsy, recent change in medication for diabetes or hyperlipidemia
Other
- pregnancy
Who the study is looking for
- known diagnosis of MASLD by histology, also have diabetes/ obesity
- on treatment with GLP-1 RA at stable dose
Age in the registry: 18 years to 80 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Froedtert Hospital | Milwaukee | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.