NCT06984237Active, not recruiting
Evaluation of Salivary and Serum Levels of TNF-α, IL-17A, and YKL-40 in Individuals With Psoriasis
Psoriasis and Periodontitis Are Chronic Inflammatory Diseases That May Share Common Immunopathogenic Pathways. TNF-α, IL-17A, and YKL-40 Are Inflammatory Biomarkers Associated With Both Conditions. This Study Aims to Evaluate the Levels of These Markers in Saliva and Serum of Individuals With Psoriasis, Considering Their Periodontal Status, to Investigate a Potential Link Between the Two Diseases
Source: ClinicalTrials.gov · Last updated 22 May 2025
Brief summary (registry, in English)
Background: Periodontitis is a chronic inflammatory disease triggered by microbial infections that lead to the destruction of tissues supporting the teeth. Psoriasis is a chronic skin condition characterized by excessive proliferation and abnormal differentiation of keratinocytes. Due to the presence of similar inflammatory mechanisms, an immunological relationship between psoriasis and periodontal disease has been hypothesized. To explore this relationship, the levels of TNF-α, IL-17A, and YKL-40 in saliva and serum will be examined in both systemically healthy individuals and individuals with psoriasis. Methods: The study will include five distinct groups based on systemic and periodontal conditions: 1. systemically and periodontally healthy individuals (H), 2. systemically healthy individuals with gingivitis (Control Gingivitis, CG), 3. systemically healthy individuals with periodontitis (Control Periodontitis, CP), 4. individuals with psoriasis and gingivitis (Psoriasis Gingivitis, PG), and 5. individuals with psoriasis and periodontitis (Psoriasis Periodontitis, PP). Levels of TNF-α, IL-17A, and YKL-40 will be measured in both saliva and serum samples. Additionally, correlations among these cytokines and between cytokine levels and clinical periodontal parameters-including Plaque Index (PI), Bleeding on Probing (BOP), Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL)-will be analyzed. Conclusion: The study is expected to provide insight into the immunological link between psoriasis and periodontal disease by evaluating TNF-α, IL-17A, and YKL-40 levels at both local (saliva) and systemic (serum) levels.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (actual)
- First submitted
- 8 May 2025
- Start date
- 2 Dec 2024
- Primary completion date
- 18 Apr 2025
- Lead sponsor
- Akdeniz University
- Diseases
- Psoriasis
- NCT number
- NCT06984237
What you commit to
- Study type: Observational
- Participants enrolled: 100
- From 2 Dec 2024 to the primary completion date, 18 Apr 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current use of systemic corticosteroids, immunosuppressive agents, or biological drugs
Other illness
- History of gingival treatment within the past 6 months
- History of any disease involving the oral mucosa (e.g., lichen planus, pemphigus vulgaris, chronic ulcerative stomatitis)
- History of systemic inflammatory diseases (e.g., rheumatoid arthritis, systemic lupus erythematosus, irritable bowel syndrome, diabetes mellitus)
Age
- Age younger than 18 or older than 65 years
Other
- Pregnancy or ongoing lactation
- Fewer than 20 natural teeth (excluding third molars)
- Current smokers
Who the study is looking for
- Voluntary participation
- No use of antibiotics within the past 6 months
- No periodontal treatment within the past 6 months
- Absence of systemic diseases known to affect periodontal health (e.g., diabetes, cardiovascular diseases)
- No infectious diseases such as tuberculosis, hepatitis, or AIDS
- Age 18 years or older
- Not pregnant (for female participants)
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Akdeniz University, Fculty of Dentistry, Akdeniz University Hospital Coordinator of this site? Confirm its status | Antalya | Turkey (Türkiye) | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.