NCT06984510Recruiting
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population
Accelerated Biological Aging is Associated With Increased Risk of T2DM in the MASLD Population: a Cohort Study
Source: ClinicalTrials.gov · Last updated 4 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The association between biological aging and type 2 diabetes mellitus (T2DM) incidence in individuals with and without metabolic dysfunction-associated steatotic liver disease (MASLD) remains unclear.We assessed biological age by calculating phenotypic age (PhenoAge), Klemera-Doubal method (KDMAge), and homeostatic dysregulation (HDAge). To examine the association of biological ageing with the risk of T2DM, cox regression models were conducted. Furthermore, we applied survival analysis, restricted cubic spline models and population attributable fraction (PAF) to further evaluate the association between biological ageing and T2DM incidence.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 2720 (estimated)
- First submitted
- 11 May 2025
- Start date
- 1 Apr 2025
- Primary completion date
- 31 Dec 2025
- Lead sponsor
- Ningbo No. 1 Hospital
- NCT number
- NCT06984510
What you commit to
- Study type: Observational
- Planned participants: 2720
- From 1 Apr 2025 to the primary completion date, 31 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Other causes of hepatic steatosis (e.g., alcoholic liver disease or hepatitis B infection)
- Type 2 diabetes mellitus at baseline
Lab values
- Missing baseline data for any of the following variables: systolic blood pressure, albumin, alkaline phosphatase, blood urea nitrogen, creatinine, glycated hemoglobin (HbA1c), total cholesterol, lymphocyte percentage, white blood cell count, mean corpuscular volume, uric acid, fasting plasma glucose, and red cell distribution width (RDW)
Age
- Age \<20 or \>90 years
Who the study is looking for
- Abdominal ultrasound data available in annual health check-up records
- At least one of the following five metabolic indicators recorded annually:
- (1) Body mass index (BMI) or waist circumference (2) Blood pressure (3) Serum triglycerides (4) High-density lipoprotein cholesterol (HDL-C) (5) Fasting plasma glucose or glycated hemoglobin (HbA1c)
Age in the registry: 20 years to 90 years · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| the First Affiliated Hospital of Ningbo University Ningbo, Zhejiang, China, 315000 Coordinator of this site? Confirm its status | Ningbo | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.