NCT06985225Recruiting
Evaluation of Ventilation Defects Downstream of Mucus Plugs in Patients With Muco-Obstructive Lung Disease
Source: ClinicalTrials.gov · Last updated 1 Jul 2026
Brief summary (registry, in English)
In this study, xenon MRI will be used to evaluate regional functional consequences of mucus plugs in the lungs of patients with muco-obstructive pulmonary disease. Mucus plugs will be identified using CT imaging, and xenon MRI will be used to evaluate ventilation and gas exchange impairments in regions of the lungs corresponding to the airways downstream of mucus plugs.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 8 (estimated)
- First submitted
- 14 May 2025
- Start date
- 1 Jun 2025
- Primary completion date
- Dec 2026
- Lead sponsor
- University of Kansas Medical Center
- Diseases
- Cystic fibrosis, Asthma, COPD
- NCT number
- NCT06985225
What you commit to
- Study type: Observational
- Planned participants: 8
- From 1 Jun 2025 to the primary completion date, Dec 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Respiratory tract infection within the 4 weeks prior to Visit 1
- One-time doses such as intra-articular injections require a 4-week washout prior to Visit 1
- ER visit related to pulmonary condition within the previous 4 weeks of Visit 1
- Significant concomitant medical illness, including (but not limited to) heart disease, cancer, uncontrolled diabetes, other chronic lung diseases (determined by the Investigator.)
- Participation in an intervention study (including bronchoscopy) or use of investigative drugs within the past 30 days or plans to enroll in such a trial during the study
Other illness
- Conditions that will prohibit MRI scanning determined by the MRI safety screening.
Other
- Body mass index (BMI) \> 30 at Visit 1
- Resting O2 saturation \<90% with maximum supplemental O2 delivered by nasal canula
- Positive urine pregnancy test
- Unable or unlikely to complete study assessments in the opinion of the Investigator
- Study intervention poses undue risk to patient in the opinion of the Investigator
Who the study is looking for
- Adequate completion of informed consent process with written documentation
- Patients 18 - 65 years old
- • Physician diagnosis of muco-obstructive pulmonary disease, including cystic fibrosis, severe asthma, chronic obstructive pulmonary disease, or non-cystic fibrosis bronchiectasis for \> 1 year
- Able to perform reproducible spirometry according to ATS criteria based on clinical PFTs.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Kansas Medical Center Coordinator of this site? Confirm its status | Kansas City | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.