NCT06986278Recruiting
tdCS Combined With Treadmill Training in Patients With Multiple Sclerosis
Transcranial Direct Current Stimulation Combined With Treadmill Training With Partial Body Weight Support in Patients With Multiple Sclerosis
Source: ClinicalTrials.gov · Last updated 29 May 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This clinical trial aims to evaluate the therapeutic effectiveness of transcranial direct current stimulation (tDCS), a non-invasive technique that modulates cortical excitability, in combination with gait training in patients with multiple sclerosis (MS). The study focuses on improving balance and walking ability, which are commonly impaired in this population. A randomized, triple-blind, controlled design will be used, comparing an active tDCS group with a sham stimulation group, both receiving the same gait training protocol. Outcomes will include functional and clinical measures related to mobility, balance, and fatigue. The project builds on previous meta-analytical evidence suggesting positive effects of tDCS in MS and aims to confirm these findings using an optimized stimulation protocol.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 78 (estimated)
- First submitted
- 7 May 2025
- Start date
- 26 May 2025
- Primary completion date
- 31 Aug 2025
- Lead sponsor
- University of Castilla-La Mancha
- Diseases
- Multiple sclerosis
- NCT number
- NCT06986278
What you commit to
- Study type: Interventional
- Planned participants: 78
- From 26 May 2025 to the primary completion date, 31 Aug 2025
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Uncontrolled epilepsy.
- Diagnosis of psychiatric disorder.
Other
- Peripheral neurological injury of lower limbs.
- Metal objects in the head.
- Fractures or fissures in the skull.
- Presence of any implanted electronic device (pacemaker, baclofen pump).
- Presence of ulcers in the harness attachment area.
- Osteoporotic fractures in the last 2 years.
- Height \> 190 cm.
- Weight \> 120 kg.
Who the study is looking for
- Ability to understand and follow instructions.
- Diagnosis of Multiple Sclerosis according to McDonald criteria.
- Expanded Disability Status Scale (EDSS) between 1 and 6.
- Stable condition in the last three months.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Universidad de Castilla La Mancha Coordinator of this site? Confirm its status | Toledo | Spain | Enrolling by invitation |
| Asociación de Esclerosis Múltiple de Toledo Coordinator of this site? Confirm its status | Toledo | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.