NCT06988020Recruiting
"Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma
Evaluation of Optimised Whole-body MRI Examinations Incorporating "Pseudo-scanner" Sequences (ZTE, "Zero Echo Time" AND Lava Flex) for the Detection of Bone Lesions in Multiple Myeloma
Source: ClinicalTrials.gov · Last updated 24 Apr 2026
Brief summary (registry, in English)
Recent work has confirmed the diagnostic performance of pseudo-CT sequences for detecting osteolytic lesions. Their integration into whole body MRI (WB MRI) could transform the diagnostic approach to MM, by allowing a combined assessment of bone marrow involvement, tissue viability and osteolysis, during a single non-irradiating imaging examination. Since the preliminary work mentioned above, optimizations have been made to the pseudo-CT sequences, including the addition of deep learning (correcting noise in the images) and the correction of chemical shift artifact (linked to the coexistence of hydrated tissue and fatty tissue), which carry real hope of improving their diagnostic potential and accuracy.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 15 May 2025
- Start date
- 22 Apr 2025
- Primary completion date
- Nov 2027
- Lead sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Diseases
- Multiple myeloma
- NCT number
- NCT06988020
What you commit to
- Study type: Interventional
- Planned participants: 45
- From 22 Apr 2025 to the primary completion date, Nov 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Implanted material incompatible with MRI.
- Severe claustrophobia.
- Pregnant women
Who the study is looking for
- Patient with newly diagnosed multiple myeloma, for whom bone imaging is required for staging.
- Recurrent patient after intensive treatment (high dose chemotherapy, bone marrow transplant, etc.).
- Patient requiring a PET / CT considered as the technique of choice in these stages of the disease.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Cliniques universitaires Saint-Luc Coordinator of this site? Confirm its status | Brussels | Belgium | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.