NCT06988202Enrolling by invitation
Comparative Effectiveness of Different Techniques for Repeat Ablation of Atrial Fibrillation
Comparative Effectiveness of Different Techniques for Repeat Ablation After Failed Initial Ablation for Persistent Atrial Fibrillation
Source: ClinicalTrials.gov · Last updated 23 Mar 2026
Brief summary (registry, in English)
Atrial fibrillation (AF) is the most common type of irregular heartbeat doctors see. People with AF sometimes have a procedure called an ablation to help get their heart back into a normal rhythm. However, this treatment doesn't always work. This study is looking at whether adding an extra step to the usual ablation-specifically treating another area of the heart called the left atrial (LA) posterior wall-can help people feel better overall, compared to just repeating the standard pulmonary vein isolation ablation procedure.
- Status (registry)
- Enrolling by invitation
- Study type
- Interventional
- Enrollment
- 630 (estimated)
- First submitted
- 15 May 2025
- Start date
- 18 Mar 2026
- Primary completion date
- 1 Jan 2030
- Lead sponsor
- University of Rochester
- Diseases
- Atrial fibrillation
- NCT number
- NCT06988202
What you commit to
- Study type: Interventional
- Planned participants: 630
- From 18 Mar 2026 to the primary completion date, 1 Jan 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior ablation that included non-PVI LA ablation, or more than one prior PVI ablation procedure for persistent AF
- Prior surgical ablation for AF
- Acute coronary syndrome or coronary artery bypass surgery or percutaneous coronary intervention (balloon and/or stent angioplasty) within 3 calendar months prior to consent date
- Enzyme-positive myocardial infarction within the past 3 calendar months prior to consent
- Prior valve replacement with mechanical prosthesis
- Stroke within 3 calendar months prior to consent date
Other illness
- NYHA class III-IV congestive heart failure
- Severe aortic or mitral valvular heart disease eligible for percutaneous or surgical repair/replacement procedures
- Angiographic evidence of coronary disease that requires coronary revascularization and with likelihood of undergoing a CABG or PCI in the next 3 calendar months following consent date
- Any medical condition likely to limit survival to \< 1 year
- Renal failure requiring dialysis at time of consent
- History of non-compliance to medical therapy
Lab values
- LV ejection fraction \< 35%
Other
- Inability to undergo AF catheter ablation (e.g., presence of a left atrial thrombus)
- Contraindication to systematic anticoagulation
- LA diameter on echocardiogram \> 6.0 cms
- Pregnancy
- Participation in other clinical trials (observational/lead registries are allowed) without approval from the CCRC
- Inability or unwillingness to provide informed consent
- Resides at such a distance from the enrolling site so travel to follow-up visits would be unusually difficult
- Does not anticipate residing in the vicinity of the enrolling site for the duration of the trial
Who the study is looking for
- Age ≥ 18 years on date of consent
- One prior PVI ablation procedure \> 3 months prior for persistent AF
- Recurrent paroxysmal or persistent symptomatic AF confirmed on ECG despite prior PVI
- Eligible for repeat ablation procedure
- Willingness to comply with all post-procedural follow-up requirements and to sign informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Rochester Clinical Cardiovascular Research Center Coordinator of this site? Confirm its status | Rochester | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.