NCT06989242Not yet recruiting
Yoga-based, Movement Therapy Device as Noninvasive Glymphatic Clearance Augmentation in Alzheimer's Disease.
Yoga-based, Movement Therapy Device as Noninvasive Glymphatic Clearance Augmentation in Alzheimer's Disease. The Feasibility and Safety Trial With Preliminary Clinical, Digital, and Fluid Biomarker Proxies of Glymphatic Clearance
Source: ClinicalTrials.gov · Last updated 10 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This clinical trial evaluates a yoga-based intervention delivered through a powered therapeutic device designed to guide breathing and body movements. Building on evidence that mind-body practices may promote healthy aging, cognitive function, and glymphatic flow, the study uses physiological measurements, including fNIRS and wearable sensors, to investigate mechanisms and potential benefits in individuals at risk for Alzheimer's disease.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 6 May 2025
- Start date
- 1 Jul 2025
- Primary completion date
- 28 Feb 2026
- Lead sponsor
- CIATRIX, INC.
- Diseases
- Alzheimer disease
- NCT number
- NCT06989242
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Jul 2025 to the primary completion date, 28 Feb 2026
- 3 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Regular use of muscle relaxants or anti-anxiety drugs
- Any muscle or skeletal issues that would make it difficult to lie still in the supine position for the 1-hour physical therapy
- Spinal injuries, clinically relevant disc herniation, spinal stenosis, spondylolisthesis in the sacral, lumbar, thoracic, or cervical spine, spinal bifida, Recent Spinal Surgery
Other illness
- Craniospinal disorders, e.g., Chiari Malformation.
- History of neurological disorders such as stroke (during the last year before study start), mild brain injury within past 6 months, multiple sclerosis, presence of intracranial hemorrhage, hydrocephalus, meningitis, encephalitis, brain tumor (except of asymptomatic meningioma GI)
- Serious sleep disorders - narcolepsy
- Major or uncontrolled psychiatric illness or major depression.
- Any condition requiring the use of medication that acts on the brain such as stimulants, sedatives (hypnotics and benzodiazepines), antipsychotics, and anti-anxiety medications, (we will include patients with stable antidepressant treatment and being on mild anti-seizure medication due to polyneuropathy)
- Active infection or uncontrolled significant systemic illnesses
- Asthma, chronic obstructive pulmonary disease
- Recent hearth attack, Implantable defibrillator, poorly controlled blood pressure cardiac arrhythmia, unstable angina pectoris, or symptomatic congestive heart failure
- People at risk of blood clots or deep vein thrombosis (DVT) might want to avoid prolonged sitting in the chair
Other
- Inability to provide informed consent
- Severe osteoporosis with a risk of fracture
- Obesity over 135 kg (300lb)
- Smoking more than 5 cigarettes a day or drinking more than 1 alcoholic beverage a day
Who the study is looking for
- 55-85 years of age
- Current diagnostic criteria for stage 3 AD patients (AD-MCI)
- Current diagnostic criteria for stage 4 AD patients (mAD)
- Able to provide consent to be in the study
- Willing and able to participate in study activities
- Able to lay supine for 30-45 minutes
- Able to walk 20 meters
- Willing to not perform additional mind-body practices during the duration of the study
- Able to use a wearable electronic device (Smart watch)
Age in the registry: 55 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Neuro Health Centrum S.R.O Coordinator of this site? Confirm its status | Brno | Czechia | Unknown status |
| Neuropsychiatrie s.r.o., Terronska 580/19 Coordinator of this site? Confirm its status | Prague | Czechia | Unknown status |
| AuraMedica s.r.o., Neurologická ambulancia, OMNIA BUSINESS CENTER, Tomášikova 19081/28C Coordinator of this site? Confirm its status | Bratislava | Slovakia | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.