NCT06989359RecruitingPhase 2
Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease
A Phase 2 Study to Assess ADX-038 in Participants With Complement-Mediated Kidney Disease
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
This Phase 2 study is designed to assess the safety, efficacy, pharmacokinetics (PK) and pharmacodynamics (PD) of ADX-038 in adults with complement-mediated kidney diseases.
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 45 (estimated)
- First submitted
- 22 May 2025
- Start date
- 28 Aug 2025
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- ADARx Pharmaceuticals, Inc.
- Diseases
- IgA nephropathy
- NCT number
- NCT06989359
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 45
- From 28 Aug 2025 to the primary completion date, 31 Dec 2028
- 32 sites in 8 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Kidney transplant or renal replacement therapy
- Received complement inhibitor treatments
Other illness
- History of solid organ transplant
- Other kidney disease
- History of recurrent invasive infections
- Active systemic viral, bacterial, or fungal infection
Other
- Hereditary or acquired complement deficiency
- Abnormal liver function
Who the study is looking for
- Mean eGFR greater than or equal to 30 mL/min/1.73m2
- Clinical evidence of active kidney disease
- Treated with supportive care including an ACE inhibitor or ARB if applicable
- Willing to receive required vaccinations
- Primary diagnosis of IgAN, C3G or IC-MPGN confirmed by a kidney biopsy
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (32)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| ADARx Clinical Site Coordinator of this site? Confirm its status | Liverpool | Australia | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Sydney | Australia | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Wollongong | Australia | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Woolloongabba | Australia | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Seville | Spain | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Leicester | United Kingdom | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Newcastle upon Tyne | United Kingdom | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Hong Kong | Hong Kong SAR China | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Shatin | Hong Kong SAR China | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Bergamo | Italy | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Bologna | Italy | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Pavia | Italy | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Cheonan | South Korea | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Daegu | South Korea | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Gyeonggi-do | South Korea | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Seoul | South Korea | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Wŏnju | South Korea | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Kaohsiung City | Taiwan | Not yet recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | New Taipei City | Taiwan | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Columbus | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Dakota Dunes | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Dallas | United States | Withdrawn |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Doral | United States | Withdrawn |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Great Neck | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Iowa City | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Pembroke Pines | United States | Withdrawn |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Shelby | United States | Recruiting |
| ADARx Clinical Site Coordinator of this site? Confirm its status | Shreveport | United States | Withdrawn |
This page is information, not medical advice. Discuss any trial with your doctor.