NCT06991257RecruitingPhase 2
A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF AN ORAL BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE INHIBITOR, PF-07328948, IN ADULTS WITH HEART FAILURE (BRANCH-HF)
Source: ClinicalTrials.gov · Last updated 23 Oct 2026
Brief summary (registry, in English)
The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 620 (estimated)
- First submitted
- 19 May 2025
- Start date
- 19 Jun 2025
- Primary completion date
- 8 May 2028
- Lead sponsor
- Pfizer
- Diseases
- Heart failure
- NCT number
- NCT06991257
- EU CT number
- 2024-518438-94-00
What you commit to
- Study type: Interventional · Phase 2
- Planned participants: 620
- From 19 Jun 2025 to the primary completion date, 8 May 2028
- 152 sites in 14 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Major surgery scheduled for the duration of the study, affecting walking ability in the opinion of the study doctor.
- Prior intolerance/known hypersensitivity to an SGLT2 inhibitor or contraindication to an SGLT2 inhibitor
Other illness
- Type 1 diabetes mellitus, liver cirrhosis or any condition that can possibly affect how the medicine is absorbed into the body.
- History of heart transplantation, or currently listed for a heart transplant, or current planned use of IV vasodilators and/ or inotropes
Who the study is looking for
- aged 18 years to \< 80 years
- clinically confirmed to have a diagnosis of heart failure for at least 3 months
- New York Heart Association Class II-IV symptoms
- left ventricular ejection fraction greater than 40%
- Kansas City Cardiomyopathy Questionnaire-23 Total Symptom Score \< 85
- Six-minute walking distance greater than 75 meters
Criteria the registry did not label
- This study is seeking participants who are:
Age in the registry: 18 years to 79 years · Sex: All · Does not accept healthy volunteers
Sites (152)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CEMEDIC Coordinator of this site? Confirm its status | CABA | Argentina | Not yet recruiting |
| Instituto Médico DAMIC Coordinator of this site? Confirm its status | Córdoba | Argentina | Recruiting |
| Hospital Privado Universitario de Córdoba Coordinator of this site? Confirm its status | Córdoba | Argentina | Not yet recruiting |
| DIM Clínica Privada Coordinator of this site? Confirm its status | Ramos Mejía | Argentina | Recruiting |
| Sanatorio Británico Coordinator of this site? Confirm its status | Rosario | Argentina | Recruiting |
| Corporación Médica San Martín Coordinator of this site? Confirm its status | San Martin | Argentina | Not yet recruiting |
| Centro de Investigaciones Clinicas del Litoral Coordinator of this site? Confirm its status | Santa Fe | Argentina | Recruiting |
| Mnogoprofilna Bolnitsa Za Aktivno Lechenie Puls AD Coordinator of this site? Confirm its status | Blagoevgrad | Bulgaria | Recruiting |
| Multiprofile Hospital For Active Treatment "Dr. Tota Venkova" AD Coordinator of this site? Confirm its status | Gabrovo | Bulgaria | Recruiting |
| Medical Center Hera - Kyustendil EOOD Coordinator of this site? Confirm its status | Kyustendil | Bulgaria | Recruiting |
| Diagnostic Consultative Center - 1 Lom EOOD Coordinator of this site? Confirm its status | Lom | Bulgaria | Recruiting |
| Multi-profile Hospital for Active Treatment Heart and Brain EAD Coordinator of this site? Confirm its status | Pleven | Bulgaria | Recruiting |
| University Multiprofile Hospital For Active Treatment Saint Georgi EAD Coordinator of this site? Confirm its status | Plovdiv | Bulgaria | Recruiting |
| Multiprofile Hospital For Active Treatment Hadji Dimitar OOD Coordinator of this site? Confirm its status | Sliven | Bulgaria | Recruiting |
| University Multidisciplinary Hospital For Active Treatment Sveta Ekaterina EAD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Recruiting |
| Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EAD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Recruiting |
| Diagnostic Consultative Centre Ascendent EOOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Recruiting |
| Acibadem City Clinic University Multiprofile Hospital For Active Treatment EOOD Coordinator of this site? Confirm its status | Sofia | Bulgaria | Recruiting |
| Medical Center Hera EOOD Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Recruiting |
| Diagnostic-Consultative Center Alexandrovska EOOD Coordinator of this site? Confirm its status | Sofiya | Bulgaria | Recruiting |
| Cardresearch - Cardiologia Assistencial e Pesquisa Coordinator of this site? Confirm its status | Belo Horizonte | Brazil | Recruiting |
| UNESP - Faculdade de Medicina da Universidade Estadual Paulista Coordinator of this site? Confirm its status | Botucatu | Brazil | Recruiting |
| L2IP - Instituto de Pesquisas Clínicas Coordinator of this site? Confirm its status | Brasília | Brazil | Recruiting |
| Instituto de Pesquisa Clínica de Campinas Coordinator of this site? Confirm its status | Campinas | Brazil | Recruiting |
| CoraCentro Pesquisa Clinica Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Recruiting |
| Nucleo de Pesquisa Clínica do Rio Grande do Sul Coordinator of this site? Confirm its status | Porto Alegre | Brazil | Recruiting |
| Centro Avançado De Pesquisa, Estudos E Diagnóstico (CAPED) - Centro Médico RibeirãoShopping Coordinator of this site? Confirm its status | Ribeirão Preto | Brazil | Recruiting |
| Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Coordinator of this site? Confirm its status | São José do Rio Preto | Brazil | Recruiting |
| CEPIC - Centro Paulista de Investigação Clínica Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| Incor - Instituto do Coracao Coordinator of this site? Confirm its status | São Paulo | Brazil | Recruiting |
| CIUSSS- saguenay-Lac-Saint-Jean Coordinator of this site? Confirm its status | Chicoutimi | Canada | Recruiting |
| ACV Clinic Coordinator of this site? Confirm its status | Greater Sudbury | Canada | Recruiting |
| Health Sciences North Research Institute Coordinator of this site? Confirm its status | Greater Sudbury | Canada | Recruiting |
| QEII Health Sciences Centre, Victoria General Site Coordinator of this site? Confirm its status | Halifax | Canada | Recruiting |
| CHU de Quebec-Universite Laval-Hotel Dieu de Quebec Coordinator of this site? Confirm its status | Québec | Canada | Recruiting |
| Richmond Clinical Trials Coordinator of this site? Confirm its status | Richmond | Canada | Active, not recruiting |
| CardioQuest Research Centre Coordinator of this site? Confirm its status | Sarnia | Canada | Recruiting |
| Clinique de Médecins Spécialistes Coordinator of this site? Confirm its status | Shebrooke | Canada | Recruiting |
| Diex Recherche Sherbrooke Est Coordinator of this site? Confirm its status | Sherbrooke | Canada | Recruiting |
| Centre intégré de santé et de services sociaux de Lanaudière - Hopital Pierre-Le Gardeur. Coordinator of this site? Confirm its status | Terrebonne | Canada | Recruiting |
| Corcare Coordinator of this site? Confirm its status | Toronto | Canada | Recruiting |
| Diex Recherche Trois-Rivieres Coordinator of this site? Confirm its status | Trois-Rivières | Canada | Recruiting |
| Winchester District Memorial Hospital Coordinator of this site? Confirm its status | Winchester | Canada | Recruiting |
| Community Care Building Coordinator of this site? Confirm its status | Winchester | Canada | Recruiting |
| Peking University First Hospital Coordinator of this site? Confirm its status | Beijing | China | Recruiting |
| China-Japan Union Hospital Coordinator of this site? Confirm its status | Changchun | China | Recruiting |
| The Second Xiangya Hospital of Central South University Coordinator of this site? Confirm its status | Changsha | China | Recruiting |
| Guangdong Provincial People's Hospital Coordinator of this site? Confirm its status | Guangzhou | China | Recruiting |
| Hainan General Hospital Coordinator of this site? Confirm its status | Haikou | China | Recruiting |
| The First Affiliated Hospital of University of South China Coordinator of this site? Confirm its status | Hengyang | China | Recruiting |
| Jinan Central Hospital Coordinator of this site? Confirm its status | Jinan | China | Recruiting |
| Lanzhou University Second Hospital Coordinator of this site? Confirm its status | Lanzhou | China | Recruiting |
| Zhongshan Hospital,Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
| Shanghai Tongji Hospital Coordinator of this site? Confirm its status | Shanghai | China | Recruiting |
| The First Hospital of Hebei Medical University Coordinator of this site? Confirm its status | Shijiazhuang | China | Recruiting |
| Tianjin People's Hospital Coordinator of this site? Confirm its status | Tianjin | China | Recruiting |
| Shaanxi provincial people's hospital Coordinator of this site? Confirm its status | Xi'an | China | Recruiting |
| EFERTUS healthcare s.r.o. Coordinator of this site? Confirm its status | Brno | Czechia | Recruiting |
| Kardiologicka ambulance Brno s.r.o. Coordinator of this site? Confirm its status | Brno-Královo Pole | Czechia | Recruiting |
| Fakultni nemocnice Hradec Kralove Coordinator of this site? Confirm its status | Hradec Králové | Czechia | Recruiting |
| EDUMED s.r.o. Coordinator of this site? Confirm its status | Jaroměř | Czechia | Recruiting |
| Sdruzene zdravotnicke zarizeni Krnov příspěvková organizace Coordinator of this site? Confirm its status | Krnov | Czechia | Recruiting |
| VASOMED Clinic s.r.o. Coordinator of this site? Confirm its status | Ostrava | Czechia | Recruiting |
| AGEL Stredomoravska nemocnicni a.s. Coordinator of this site? Confirm its status | Prerov | Czechia | Recruiting |
| Hospital de la Santa Creu i Sant Pau Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital del Mar Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitari Vall d'Hebron Coordinator of this site? Confirm its status | Barcelona | Spain | Recruiting |
| Hospital Universitario Reina Sofia Coordinator of this site? Confirm its status | Córdoba | Spain | Recruiting |
| Bellvitge University Hospital Coordinator of this site? Confirm its status | L'hospitalet De Llobregat | Spain | Recruiting |
| Hospital Universitario La Paz Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Hospital Universitario Ramón y Cajal Coordinator of this site? Confirm its status | Madrid | Spain | Recruiting |
| Hospital Universitario Puerta de Hierro de Majadahonda Coordinator of this site? Confirm its status | Majadahonda | Spain | Recruiting |
| Fundacion Publica Galega Instituto De Investigacion Sanitaria De Santiago De Compostela Coordinator of this site? Confirm its status | Santiago De Compostela | Spain | Recruiting |
| Hospital Clinico Universitario de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Recruiting |
| Hospital Universitario Y Politecnico La Fe Coordinator of this site? Confirm its status | Valencia | Spain | Recruiting |
| Consorcio Hospital General Universitario de Valencia Coordinator of this site? Confirm its status | Valencia | Spain | Recruiting |
| Centre Hospitalier Universitaire Grenoble Alpes Coordinator of this site? Confirm its status | Grenoble Cedex 9 | France | Recruiting |
| Centre Hospitalier Universitaire de Montpellier Coordinator of this site? Confirm its status | Montpellier | France | Recruiting |
| Centre Hospitalier Universitaire de Nantes Coordinator of this site? Confirm its status | Saint-Herblain | France | Recruiting |
| Centre Hospitalier Intercommunal Toulon / La Seine-Sur-Mer Coordinator of this site? Confirm its status | Toulon | France | Recruiting |
| South Eastern Health and Social Care Trust Coordinator of this site? Confirm its status | Belfast | United Kingdom | Recruiting |
| St Richard's Hospital Coordinator of this site? Confirm its status | Chichester | United Kingdom | Recruiting |
| Ninewells Hospital and Medical School Coordinator of this site? Confirm its status | Dundee | United Kingdom | Recruiting |
| Wycombe General Hospital Coordinator of this site? Confirm its status | High Wycombe | United Kingdom | Recruiting |
| St. George's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Recruiting |
| Norfolk and Norwich University Hospitals NHS Foundation Trust Coordinator of this site? Confirm its status | Norwich | United Kingdom | Recruiting |
| Northern General Hospital Coordinator of this site? Confirm its status | Sheffield | United Kingdom | Recruiting |
| Budapesti Jahn Ferenc Del-pesti Korhaz es Rendelointezet Coordinator of this site? Confirm its status | Budapest | Hungary | Recruiting |
| Ezustfeny Klinika Kft. Coordinator of this site? Confirm its status | Budapest X | Hungary | Recruiting |
| Semmelweis University Coordinator of this site? Confirm its status | Budapest XII | Hungary | Recruiting |
| Central Hospital Of Northern Pest Military Hospital Coordinator of this site? Confirm its status | Budapest XIII | Hungary | Recruiting |
| BKS Research Kft Coordinator of this site? Confirm its status | Hatvan | Hungary | Recruiting |
| Da Vinci Spa Kft. Coordinator of this site? Confirm its status | Pecs | Hungary | Recruiting |
| New Medical Center Kft. Coordinator of this site? Confirm its status | Sopron | Hungary | Recruiting |
| Complex Rendelo Med Zrt. Coordinator of this site? Confirm its status | Székesfehérvár | Hungary | Recruiting |
| National Hospital Organization Iwakuni Clinical Center Coordinator of this site? Confirm its status | Iwakuni | Japan | Recruiting |
| Kasugai Municipal Hospital Coordinator of this site? Confirm its status | Kasugai | Japan | Recruiting |
| Nagoya Tokushukai General Hospital Coordinator of this site? Confirm its status | Kasugai | Japan | Recruiting |
| Kishiwada Tokushukai Hospital Coordinator of this site? Confirm its status | Kishiwada | Japan | Recruiting |
| Showa General Hospital Coordinator of this site? Confirm its status | Kodaira-shi | Japan | Recruiting |
| Koga General Hospital Coordinator of this site? Confirm its status | Koga | Japan | Recruiting |
| Seikeikai New Tokyo Heart Clinic Coordinator of this site? Confirm its status | Matsudo | Japan | Recruiting |
| National Hospital Organization Tokyo Medical Center Coordinator of this site? Confirm its status | Meguro-Ku | Japan | Recruiting |
| Nagasaki Harbor Medical Center Coordinator of this site? Confirm its status | Nagasaki | Japan | Recruiting |
| Sagamihara Kyodo Hospital Coordinator of this site? Confirm its status | Sagamihara | Japan | Recruiting |
| Teine Keijinkai Hospital Coordinator of this site? Confirm its status | Sapporo | Japan | Recruiting |
| National Hospital Organization Sendai Medical Center Coordinator of this site? Confirm its status | Sendai | Japan | Recruiting |
| NewHeart Watanabe Institute Coordinator of this site? Confirm its status | Suginami | Japan | Recruiting |
| Tokyo Metropolitan Toshima Hospital Coordinator of this site? Confirm its status | tabashi City | Japan | Recruiting |
| Sekino Hospital Coordinator of this site? Confirm its status | Toshimaku | Japan | Recruiting |
| National Hospital Organization Mie Chuo Medical Center Coordinator of this site? Confirm its status | Tsu | Japan | Recruiting |
| National Hospital Organization Saitama Hospital Coordinator of this site? Confirm its status | Wako | Japan | Recruiting |
| Yokohama Municipal Citizen's Hospital Coordinator of this site? Confirm its status | Yokohama | Japan | Recruiting |
| National Hospital Organization Yokohama Medical Center Coordinator of this site? Confirm its status | Yokohama | Japan | Recruiting |
| Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j. Coordinator of this site? Confirm its status | Bydgoszcz | Poland | Recruiting |
| Kardio Brynów Sp. z o.o. Coordinator of this site? Confirm its status | Katowice | Poland | Recruiting |
| Miejski Szpital Zespolony w Olsztynie Coordinator of this site? Confirm its status | Olsztyn | Poland | Recruiting |
| Uniwersytecki Szpital Kliniczny w Poznaniu Coordinator of this site? Confirm its status | Poznan | Poland | Recruiting |
| Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Pulawach Coordinator of this site? Confirm its status | Pulawy | Poland | Recruiting |
| NZOZ Sopockie Centrum Badań Kardiologicznych Pro Cordis Coordinator of this site? Confirm its status | Sopot | Poland | Recruiting |
| Wojewodzki Szpital Zespolony im. L. Rydygiera w Toruniu Coordinator of this site? Confirm its status | Torun | Poland | Recruiting |
| Research and Cardiovascular Corp Coordinator of this site? Confirm its status | Ponce | Puerto Rico | Recruiting |
| Ascension Saint Agnes Heart Care Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
| National Heart Institute Coordinator of this site? Confirm its status | Beverly Hills | United States | Active, not recruiting |
| Chesapeake Cardiac Care Coordinator of this site? Confirm its status | Bowie | United States | Recruiting |
| Flourish Research - Bowie Coordinator of this site? Confirm its status | Bowie | United States | Recruiting |
| Headlands Horizons, LLC dba Headlands Research-Brownsville Coordinator of this site? Confirm its status | Brownsville | United States | Recruiting |
| Valley Regional Medical Center Coordinator of this site? Confirm its status | Brownsville | United States | Recruiting |
| Northwestern Memorial HealthCare - Feinberg Pavilion Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Northwestern Memorial HealthCare - Galter Pavilion Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Northwestern Memorial Hospital Investigational Drug Service (IDS) Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Northwestern Memorial HealthCare - Arkes Pavilion Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| NMH Clinical Research Unit Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Northwestern University Coordinator of this site? Confirm its status | Evanston | United States | Recruiting |
| NexGen Research Coordinator of this site? Confirm its status | Fort Wayne | United States | Recruiting |
| Texas Health Physicians Group Coordinator of this site? Confirm its status | Fort Worth | United States | Recruiting |
| Texas Health Research & Education Institute - Fort Worth Coordinator of this site? Confirm its status | Fort Worth | United States | Recruiting |
| Chicago Medical Research Coordinator of this site? Confirm its status | Hazel Crest | United States | Recruiting |
| Jacksonville Center for Clinical Research Coordinator of this site? Confirm its status | Jacksonville | United States | Recruiting |
| Orange County Research Center Coordinator of this site? Confirm its status | Lake Forest | United States | Active, not recruiting |
| NexGen Research Coordinator of this site? Confirm its status | Lima | United States | Recruiting |
| Velocity Clinical Research, Lincoln, Pioneer Heart Institute Coordinator of this site? Confirm its status | Lincoln | United States | Recruiting |
| North Dallas Research Associates Coordinator of this site? Confirm its status | McKinney | United States | Recruiting |
| Flourish Research Acquisition, LLC dba Flourish Research - North Miami Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Infinite Clinical Research Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| Amavita Research Services Coordinator of this site? Confirm its status | North Miami Beach | United States | Recruiting |
| DBC Research USA, Corp Coordinator of this site? Confirm its status | Pembroke Pines | United States | Recruiting |
| Reid Physician Associates Coordinator of this site? Confirm its status | Richmond | United States | Recruiting |
| FOMAT Medical Research Coordinator of this site? Confirm its status | Santa Maria | United States | Recruiting |
| Comprehensive Cardiovascular Care Coordinator of this site? Confirm its status | Santa Maria | United States | Recruiting |
| Northwest Houston Heart Center Coordinator of this site? Confirm its status | Tomball | United States | Recruiting |
| Clinical Site Partners, LLC dba Flourish Research Coordinator of this site? Confirm its status | Winter Park | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.