NCT06991816Active, not recruiting
The Brain&Senses Study
The Brain&Senses Study Impact of Multi Sensory Impairments on the Progression of Cognitive Decline and Reduction of Quality of Life in People Over 50ies
Source: ClinicalTrials.gov · Last updated 23 Apr 2026
Brief summary (registry, in English)
The aim of this longitudinal observational study is to evaluate the impact of sensory deficits (smell, hearing and balance on cognitive decline and quality of life in the medium term (5 years)) on a population of patients over 55. Patients will be evaluated by a neurologist, a neuropsychologist and an otolaryngologist who will perform olfactory, auditory and vestibular tests. The acquired data will then be analyzed with multivariate analysis to understand the effect of multisensory deficit on both cognition and quality of life with a particular focus on depression. The primary objective will be the evaluation of multiple deficits on cognition, the secondary will be aimed at understanding whether one sensory deficit more than another, e.g. smell versus hearing, will have a greater impact on the patient's conditions.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 100 (estimated)
- First submitted
- 24 Mar 2025
- Start date
- 1 Aug 2025
- Primary completion date
- 31 Aug 2026
- Lead sponsor
- University of Campania Luigi Vanvitelli
- Diseases
- Alzheimer disease, Parkinson disease
- NCT number
- NCT06991816
What you commit to
- Study type: Observational
- Planned participants: 100
- From 1 Aug 2025 to the primary completion date, 31 Aug 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Previous endoscopic nose + paranasal sinus surgery
- Subjects with previous stroke and outcomes
- Previous ear surgery
- previous Covid with outcomes (olfactory, vestibular, auditory and cognitive "brain fog")
Other illness
- Subjects with history of stroke in the last 3 years without outcomes
Other
- Obstructive nasal problems
- Chronic use of cortisone spray and/or systemic
- Head trauma in the last 24 months
- Patients who have been exposed to chemical agents without protection for work, e.g. carpenters
Who the study is looking for
- Patients between 60 and 85 years of age
- in general good health
- the absence of known severe psychiatric disorders
- available to be included in the study and
- to follow the 5-year follow-up.
Age in the registry: 60 years to 85 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Vanvitelli ENT department Coordinator of this site? Confirm its status | Naples | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.