NCT06993220Recruiting
Evaluating Residual Congestion at Discharge in Acute Heart Failure Patients
Multiparametric Assessment of Residual Congestion at Discharge in Patients With Acute Heart Failure
Source: ClinicalTrials.gov · Last updated 18 Jul 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
Treatment of congestion is one of the main goals in patients hospitalized for acute heart failure. Nevertheless, current evidence shows that decongestion is often not achieved and that residual congestion at discharge is strongly associated with poor outcomes. While this association has been demonstrated, previous studies have primarily focused on single parameters of congestion (physical examination, biomarkers, or imaging features). The aim of the study is to assess residual congestion at discharge using a multiparametric approach and to compare the prognostic value of each evaluation strategy. Additionally, the analysis will be supported by artificial intelligence to develop a multiparametric prognostic algorithm that can provide an improved predictive model compared to standard statistical approaches.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 500 (estimated)
- First submitted
- 19 May 2025
- Start date
- 1 Jan 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- Consorci Sanitari Integral
- Diseases
- Heart failure
- NCT number
- NCT06993220
What you commit to
- Study type: Observational
- Planned participants: 500
- From 1 Jan 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Heart transplant recipients.
- Congenital heart diseases.
- Moderate-to-severe liver disease (Child-Pugh B-C).
- Patients that will not be followed up by the Heart Failure Unit.
Other
- Known diagnosis of septicemia.
- Glomerular filtration rate \< 15 ml/min.
- Life expectancy \< 6 months.
- Active myocarditis.
- Patients with ventricular assist devices.
Who the study is looking for
- Age ≥ 18 years.
- Patients hospitalized for new onset heart failure or worsening heart failure defined by:
- Symptoms classified as New York Heart Association class III or IV.
- Clinical or instrumental signs of volume overload (e.g., dyspnea with evidence of pulmonary congestion on X-rays or lung ultrasound, pitting edema, and jugular venous distension).
- Elevated NT-proBNP levels within the first 24 hours of admission (cutoff values: 450 ng/L for patients \< 50 years; \>900 ng/L for patients aged 50-75 years; \>1800 ng/L for patients \>75 years).
- Ability to provide informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Complex Hospitalari Universitari Moisès Broggi Coordinator of this site? Confirm its status | Sant Joan Despí | Spain | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.