NCT06993597Recruiting
Study of Corneal Biomechanics in Glaucoma Patients Using Brillouin Microscopy
Development of Robust Corneal Biomechanical Biomarkers for Glaucoma Using Brillouin Microscopy
Source: ClinicalTrials.gov · Last updated 10 Aug 2026
Brief summary (registry, in English)
This pilot study evaluates the biomechanical properties of the cornea in glaucoma patients using Brillouin microscopy, a non-contact imaging technique. The study aims to compare corneal stiffness between patients with normal-tension glaucoma, high-tension glaucoma, and healthy controls, and to assess changes in corneal biomechanics following intraocular pressure (IOP)-lowering treatment. The goal is to determine whether Brillouin-derived biomechanical measurements can serve as biomarkers for glaucoma risk and progression.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 60 (estimated)
- First submitted
- 19 May 2025
- Start date
- 1 Sept 2025
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- University of Maryland, Baltimore
- Diseases
- Glaucoma
- NCT number
- NCT06993597
What you commit to
- Study type: Observational
- Planned participants: 60
- From 1 Sept 2025 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Corneal abnormalities or conditions interfering with Brillouin or applanation tonometry
- Retinal diseases affecting RNFL (e.g., macular traction)
- History of ocular surgery or laser
- Diagnosis of diabetes
- History of uveitis
- History of prolonged steroid use
- Neurodegenerative or systemic diseases (e.g., multiple sclerosis, Alzheimer's, Parkinson's, schizophrenia)
- Contraindications to beta blockers (e.g., bradycardia, severe pulmonary disease)
- History of contact lens use
Other
- Unreliable visual fields
- Moderate to severe glaucoma (per Hodapp-Anderson-Parrish criteria)
- Low blood pressure
Who the study is looking for
- \- Age 18 years or older
- Diagnosis of primary open angle glaucoma (POAG) or no history of glaucoma (for controls)
- Open angle on gonioscopy (Shaffer grade 3 or 4)
- Best-corrected visual acuity of 20/25 or better
- Refractive error between +3.00 and -5.00 diopters
- No prior use of topical glaucoma medications
- Diagnosis of:
- High Tension Glaucoma (IOP ≥ 22 mmHg on 3 visits)
- Normal Tension Glaucoma (IOP ≤ 21 mmHg on 3 visits)
- OR age-matched control with normal optic nerve and visual fields
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Maryland School of Medicine Coordinator of this site? Confirm its status | Baltimore | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.