NCT06993831Completed
ENGAGE: Virtual Reality-based Psychotherapy for Negative Symptoms in Schizophrenia
ENGAGE Pilot Study: Alleviating Negative Symptoms in Schizophrenia Using a Virtual Reality-based Intervention Targeting Social Reward Learning
Source: ClinicalTrials.gov · Last updated 9 Jan 2026
Brief summary (registry, in English)
The primary goal of this pilot study is to examine the feasibility and acceptability of a new Virtual Reality-based intervention against negative symptoms in schizophrenia spectrum disorders (SSD). The main questions it aims to answer are: 1. Is Virtual Reality-based therapy a feasible and acceptable treatment for negative symptoms in SSD? 2. Are there indications that the treatment is effective in reducing negative symptoms, improving daily functioning, and enhancing quality of life? Researchers will compare the new Virtual Reality-based treatment to standard psychiatric care to evaluate therapy effectiveness. Participants will be allocated to receive either 10 sessions of Virtual Reality-based therapy or Treatment as usual. All participants will undergo a thorough assessment at baseline and at follow-up after 12 weeks.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 30 (actual)
- First submitted
- 21 Feb 2025
- Start date
- 9 Dec 2024
- Primary completion date
- 7 Jan 2026
- Lead sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
- Diseases
- Schizophrenia
- NCT number
- NCT06993831
What you commit to
- Study type: Interventional
- Participants enrolled: 30
- From 9 Dec 2024 to the primary completion date, 7 Jan 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Current diagnosis of drug dependency
- Command of spoken Danish or English inadequate for engaging in therapy
Other illness
- Diagnosis of organic brain disease
Other
- Intellectual disability (IQ \< 70)
- Refusing to be informed on incidental findings on the MRI scans
Who the study is looking for
- ICD-10 diagnosis of a schizophrenia-spectrum disorder (F2x)
- Negative symptom score of ≥3 on the SANS items avolition or anhedonia
Age in the registry: 18 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Copenhagen Research Center for Mental Health (CORE), Mental Health Services CPH, Denmark Coordinator of this site? Confirm its status | Hellerup | Denmark | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.