NCT06995339CompletedPhase 2
Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostat on Gouty Obese Non-Diabetic Patients
Comparative Clinical and Biochemical Study Evaluating the Effectiveness of Metformin Versus Febuxostate on Gouty Obese Non-Diabetic Patients
Source: ClinicalTrials.gov · Last updated 17 Sept 2026
Brief summary (registry, in English)
Gout is a systemic disease that results from the deposition of monosodium urate crystals (MSU) in tissues. Increased serum uric acid (SUA) above a specific threshold (\>6.8 mg/dl) is a requirement for the formation of uric acid crystals. MSU crystals can be deposited in all tissues mainly in and around the joints forming tophi. Early presentation of gout is an acute joint inflammation that is quickly relieved by non-steroidal anti-inflammatory drugs (NSAIDs) or colchicine. Lowering SUA levels below deposition threshold either by dietary modification or using serum uric acid lowering drugs is the main goal in management of gout. This results in dissolution of MSU crystals preventing further attacks
- Status (registry)
- Completed
- Phase (registry)
- Phase 2
- Study type
- Interventional
- Enrollment
- 60 (actual)
- First submitted
- 20 May 2025
- Start date
- 30 May 2025
- Primary completion date
- 30 Dec 2025
- Lead sponsor
- Mostafa Bahaa
- Diseases
- Obesity
- NCT number
- NCT06995339
What you commit to
- Study type: Interventional · Phase 2
- Participants enrolled: 60
- From 30 May 2025 to the primary completion date, 30 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients with drug-induced hyperuriceamia (those taking anti-TB agents, low dose aspirin, cytotoxic chemotherapy, diuretics, immunosuppressants, fructose, lactate infusion, testosterone or xylitol).
Other illness
- The presence of any type of diabetes mellitus.
Other
- Non-obese patients with BMI \>30 kg/m2.
- Pregnant or lactating women.
Who the study is looking for
- Males or females aged \< 18 years.
- All patients are diagnosed to have gout with serum uric acid \< 7 mg/dl.
- All patients are diagnosed to have obesity with body mass index (BMI) ≥ 30 kg/m2.
Age in the registry: 18 years to 65 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Mostafa Bahaa Coordinator of this site? Confirm its status | Damietta | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.