NCT06995391Recruiting
Digitally Rendered Interventions And Knowledge To Limit Ethanol-Associated Atrial Fibrillation Severity
Source: ClinicalTrials.gov · Last updated 2 Oct 2026
Brief summary (registry, in English)
Per the 2021 National Survey on Drug Use and Health administered by the U.S. Department of Health and Human Services, 85% of all American adults consume alcohol. Atrial fibrillation (AF) is the most common arrhythmia, affecting more than 10 million individuals in U.S., comprising 4.5% of the adult population. Although alcohol abstinence clearly reduces AF in heavy drinkers, observational data comparing the health effects of limited consumption versus abstention are conflicting. The Mediterranean diet is one of the few that has demonstrated clear cardiovascular benefits in a randomized study-this diet allows for the consumption of red wine (or high polyphenol/ low alcohol alcohol), generally not more than one drink in 24 hours, with meals, avoiding spirits and binge drinking. The effect of the "Mediterranean drinking pattern" on AF risk compared to alcohol abstinence remains unknown. This single center, randomized, controlled trial aims to compare the effects of a digital health intervention to encourage durable alcohol abstinence versus allowing guideline-adherent moderate alcohol consumption on AF severity. The knowledge gained from this study may be used to determine optimal thresholds for alcohol use among AF patients.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 1000 (estimated)
- First submitted
- 20 May 2025
- Start date
- 20 Apr 2025
- Primary completion date
- 1 Mar 2030
- Lead sponsor
- University of California, San Francisco
- Diseases
- Atrial fibrillation
- NCT number
- NCT06995391
What you commit to
- Study type: Interventional
- Planned participants: 1000
- From 20 Apr 2025 to the primary completion date, 1 Mar 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Non-english speaker
- Currently pregnant or trying to get pregnant
- A healthcare professional's instruction to avoid alcohol (for any reason)
- Currently incarcerated
- Permanent AF (meaning a medical determination has been made that sinus rhythm would definitely never be pursued in this patient)
- Are unable to read or sign to provide informed consent
Who the study is looking for
- Are age 21 years or older
- Have a smartphone
- Are able to use the Eureka mobile application
- Have a history of paroxysmal or persistent atrial fibrillation (AF)
- Have consumed alcohol at least once per month on average in the past year
- Willing to receive messaging encouraging alcohol abstinence
Age in the registry: 21 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSF Medical Center at Parnassus Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.