NCT06996951RecruitingPhase 3
Sinonasal Therapies and Histologic Correlations of Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Sinonasal Therapies and Histologic Correlations for Patients With Cystic Fibrosis in the Era of Highly Effective Modulator Therapy
Source: ClinicalTrials.gov · Last updated 16 Dec 2025
Brief summary (registry, in English)
The investigators are doing this study to discover if it is appropriate for people with Cystic Fibrosis (CF) on highly effective modulator therapy (HEMT) to stop using certain standard Sino nasal therapies such as high-volume nasal saline irrigations, topical nasal steroids, and topical nasal antibiotics. They are also going to study the fluid inside the nose to see if there are changes when stopping these therapies. Right now, they are not sure if it is suggested to stop these treatments when patients begin highly effective modulator therapy (HEMT)
- Status (registry)
- Recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 64 (estimated)
- First submitted
- 14 May 2025
- Start date
- 2 Jul 2025
- Primary completion date
- Jul 2026
- Lead sponsor
- Indiana University
- Diseases
- Cystic fibrosis
- NCT number
- NCT06996951
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 64
- From 2 Jul 2025 to the primary completion date, Jul 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Cystic Fibrosis patient NOT on highly effective modulator therapy
- Not currently using topical nasal irrigations +/- additives (steroids, antibiotics)
Other illness
- History of sinonasal or nasopharyngeal tumors
- Active sinonasal infection or pulmonary infection
- Oral antibiotics within last one month for upper respiratory or lower respiratory infection
Age
- Below age of 18 years old
Other
- Pregnant patients
- Admission to hospital for pulmonary exacerbation within last 3 months
Who the study is looking for
- Age 18 or older
- Cystic Fibrosis diagnosis on HEMT
- History of chronic rhinosinusitis
- Using topical nasal irrigations +/- additives (steroids, antibiotics)
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Indiana University Health Coordinator of this site? Confirm its status | Indianapolis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.