NCT06998446Recruiting
Sodium in the Skin and Atopic Dermatitis
Source: ClinicalTrials.gov · Last updated 14 Jul 2026
Brief summary (registry, in English)
The goal of this observational study is to understand factors associated with skin sodium storage in healthy adults and people with atopic dermatitis ages 50 and above. The study is designed to test whether diet and skin barrier function are associated with skin sodium concentration and whether skin sodium concentration is linked to atopic dermatitis and immune profiles over time. Participants will be asked to complete questionnaires, provide bio samples, and undergo non-contrast sodium MRI at 2-3 time points over 3-24 months.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 12 May 2025
- Start date
- 12 May 2025
- Primary completion date
- 30 Aug 2028
- Lead sponsor
- University of California, San Francisco
- Diseases
- Atopic dermatitis (eczema)
- NCT number
- NCT06998446
What you commit to
- Study type: Observational
- Planned participants: 90
- From 12 May 2025 to the primary completion date, 30 Aug 2028
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Currently receiving phototherapy or taking systemic medications for atopic dermatitis including cyclosporine, methotrexate, or other broad immunosuppressive medications.
- (Patients on dupilumab will not be excluded if they have been on dupilumab for at least two months and still meet the criteria for severe disease.)
Other illness
- History of autoimmune disease.
- Cardiac events in the last six months.
Lab values
- Current use of medications that influence sodium excretion (e.g. thiazide diuretics, SGLT2 inhibitors and spironolactone), and/or chemotherapy or antibiotic treatment.
Other
- Impaired function of the liver or kidneys (glomerular filtration rate \<60ml/min).
Who the study is looking for
- Ages 50 years and above
- Willing to undergo non-contrast MRI (e.g., no contraindications to MRI, such as cardiac pacemakers, non-compatible intracranial vascular clips or pregnancy).
Age in the registry: 50 years to - · Sex: All · Accepts healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| UCSF Mt Zion Campus Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
| San Francisco VA Medical Center Coordinator of this site? Confirm its status | San Francisco | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.