NCT06998810Completed
Cerebellar High-Frequency rTMS in Balance of Multiple Sclerosis Patients
Effect of Cerebellar High-Frequency rTMS in Improving Balance Performance in Multiple Sclerosis Patients
Source: ClinicalTrials.gov · Last updated 31 May 2025
Brief summary (registry, in English)
Background: Multiple Sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system (CNS), leading to progressive motor dysfunction and balance deficits. Objective: To investigate the impact of cerebellar rTMS in improving postural control, balance performance and functional ambulation in individuals with MS. Forty patients were randomly assigned to receive repetitive transcranial magnetic stimulation (rTMS) over the cerebellum to improve motor function and balance in 40 MS patients. Outcome measures, including the Expanded Disability Status Scale (EDSS), static posturography (COP measures), the International Cooperative Ataxia Rating Scale (ICARS), and the 10-Meter Walk Test (10MWT), were assessed before and after intervention.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 40 (actual)
- First submitted
- 6 May 2025
- Start date
- 25 Feb 2023
- Primary completion date
- 25 Dec 2024
- Lead sponsor
- Ain Shams University
- Diseases
- Multiple sclerosis
- NCT number
- NCT06998810
What you commit to
- Study type: Interventional
- Participants enrolled: 40
- From 25 Feb 2023 to the primary completion date, 25 Dec 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Disabling medical history as severe or recent heart disease and or severe head trauma.
- Cognitive impairment: \<24 points by mini-mental scale. (Folstein MF et al., 1975).
- Patients with any other comorbidity that can affect balance, e.g, other neurological diseases that can affect posterior column function.
- Contraindications for rTMS:
- History of epilepsy.
- Metal (implants) in skull/scalp/head or fragments from welding or metalwork.
- Implanted device (as spinal cord stimulator, cardiac pacemaker, and cochlear implants).
- Pregnancy.
Other
- Factors that prevent patient cooperation understanding that impede proper study participation.
- Diabetic patients.
Who the study is looking for
- Patient age ≥18 years.
- Patients with MS, established by clinical, laboratory, MRI criteria and matched Mc Donald's criteria, McDonald et al, 2006.
- Expanded Disability Status Scale (EDSS) scores between 2.5-5
- Only patients in "remitting" phase were included.
- Informed consent.
Age in the registry: 18 years to 60 years · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Shereen Ismail Fawaz Coordinator of this site? Confirm its status | Cairo | Egypt | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.