NCT07003399Recruiting
Diaphragmatic Function and Respiratory Drive in OSA and COPD
Diaphragmatic Morphofunction and Respiratory Drive in OSA and COPD: Insights From Ultrasound and EMG-based Cross-Sectional Analysis
Source: ClinicalTrials.gov · Last updated 25 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), overlap syndrome (OS), and healthy controls. Using ultrasound imaging and surface diaphragm electromyography (EMGdi), the study will explore group differences in diaphragmatic morphology, function, and respiratory drive indicators, and evaluate their clinical significance in disease differentiation and severity assessment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 80 (estimated)
- First submitted
- 15 May 2025
- Start date
- Jan 2025
- Primary completion date
- Aug 2025
- Lead sponsor
- Nanjing Medical University
- Diseases
- COPD
- NCT number
- NCT07003399
What you commit to
- Study type: Observational
- Planned participants: 80
- From Jan 2025 to the primary completion date, Aug 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Recent upper airway or thoracic surgery (within 3 months).
Other illness
- Severe cardiovascular diseases (e.g., unstable angina, heart failure NYHA III/IV).
- Severe hepatic or renal insufficiency.
- Neuromuscular diseases affecting respiratory muscles.
- Participants who cannot complete assessments due to cognitive impairment or poor cooperation.
Other
- Pregnancy or breastfeeding.
Who the study is looking for
- Patients aged between 18 and 80 years.
- For OSA Group: Diagnosed obstructive sleep apnea with AHI ≥ 5 events/hour based on overnight polysomnography.
- For COPD Group: Diagnosed chronic obstructive pulmonary disease based on GOLD guidelines.
- For Overlap Group: Diagnosed both OSA (AHI ≥ 5) and COPD.
- For Control Group: Healthy volunteers with no known respiratory diseases or sleep disorders.
- Ability and willingness to provide informed consent for participation in the study.
Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Nanjing Medical University Coordinator of this site? Confirm its status | Nanjing | China | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.