NCT07004127Completed
Pneumocystis in Patients Over 75 Year
Pneumocystis in Non-HIV Patients Over 75 Years Old: Epidemiological, Diagnostic, Microbiological and Therapeutic Characteristics
Source: ClinicalTrials.gov · Last updated 4 Jun 2025
Brief summary (registry, in English)
Pneumocystis pneumonia is an infectious disease caused by Pneumocystis jirovecii that affects the lung parenchyma preferentially. Historically described in an immunocompromised population through HIV. Worldwide, the profile of patients affected by this pathology is changing due to two main factors: * The sustainable stabilization of HIV patients. * The emergence of new risk factors of immunosuppression. The geriatric population is particularly affected by these risk factors, increasing the incidence of pneumocystis in this population, which does not have HIV (solid cancer, hemopathy, immunosuppressive treatments, etc.). There is currently no work specifically studying pneumocystis in this age group. The main objective of this study is to describe the clinical, biological and therapeutic data of a cohort of geriatric patients with pneumocystis, not carrying HIV, from January 1, 2010 to December 31, 2021, in all the centers surveyed.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 162 (actual)
- First submitted
- 31 Aug 2022
- Start date
- 1 Jan 2010
- Primary completion date
- 31 Dec 2023
- Lead sponsor
- Centre Hospitalier Universitaire de Nīmes
- NCT number
- NCT07004127
What you commit to
- Study type: Observational
- Participants enrolled: 162
- From 1 Jan 2010 to the primary completion date, 31 Dec 2023
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Who the study is looking for
- Patient \> or equal to 75 years of age
- Microbiological diagnosis:
- Direct examination with standard stain, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum) And/or
- Direct examination with immunofluorescence, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum)
- And/or
- Positive PCR (BAL, sputum, nasopharyngeal swab or blood) and CT \< 35
- Absence of HIV infection
- Hospitalization in French hospitals between 2010 and 2021
- Non-inclusion criteria
- 1\. Opposition of the patient to participate to the study
Age in the registry: 75 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CHU de Nîmes Coordinator of this site? Confirm its status | Nîmes | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.