NCT07010614Recruiting
Brain Stimulation to the Hippocampus in Schizophrenia
Theta Burst Modulation of Hippocampal-Cortical Rhythms in Schizophrenia
Source: ClinicalTrials.gov · Last updated 27 Feb 2026
Brief summary (registry, in English)
Schizophrenia - marked by delusions, hallucinations, and cognitive deficits - causes the most disability of any mental health condition, but existing treatments have significant side effect burden and are often ineffective. Disordered neural activity in the hippocampus likely contributes to schizophrenia symptoms, but to develop better therapies we need to understand whether hippocampal activity in schizophrenia can be systematically affected by non-invasive brain stimulation techniques like transcranial magnetic stimulation (TMS). This proposal will investigate the use of connectivity-guided theta burst brain stimulation to specifically target hippocampal function in schizophrenia, offering insights into fundamental hippocampal processes, schizophrenia pathophysiology, and potential avenues to use brain stimulation as a therapeutic tool in this devastating illness.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 60 (estimated)
- First submitted
- 30 May 2025
- Start date
- 1 Oct 2025
- Primary completion date
- 30 Sept 2027
- Lead sponsor
- Stanford University
- Diseases
- Schizophrenia
- NCT number
- NCT07010614
What you commit to
- Study type: Interventional
- Planned participants: 60
- From 1 Oct 2025 to the primary completion date, 30 Sept 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Active suicidal ideation or history of suicide attempt within the past 1 year.
- Medical illness affecting brain structure or function, or other uncontrolled or unstable medical condition.
- Psychotic illness with a temporal relation to substance use or head injury
Other
- DSM5 diagnosis of intellectual disability
- Significant head injury
- Pregnancy or postpartum (\<6 weeks after delivery or miscarriage)
- Inability to provide informed consent
- Active substance abuse other than alcohol or cannabis within the past 1 year
- Those with a contraindication for MRIs or TMS (e.g. implanted metal).
Who the study is looking for
- Men and women, ages 18 to 65 years
- Medically intractable epilepsy requiring phase II monitoring (intracranial EEG arms only)
- DSM-V diagnosis of schizophrenia spectrum Axis I disorders including delusional disorder, brief psychotic disorder, schizophreniform disorder, schizophrenia, schizoaffective disorder (non-invasive TMS-EEG arms only).
- Must have intellectual capacity to ensure adequate comprehension of the study and potential risks involved in order to provide informed consent
- No current or history of major neurological disorders other than epilepsy.
Age in the registry: 18 years to 65 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University Coordinator of this site? Confirm its status | Stanford | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.