NCT07013929Recruiting
Spyral InSight Study
Spyral InSight Early Clinical Feasibility Study
Source: ClinicalTrials.gov · Last updated 20 Oct 2026
Brief summary (registry, in English)
The purpose of the Spyral InSight Early Clinical Feasibility Study is to characterize the physiological response to renal nerve stimulation (RNS) in humans prior to and post renal denervation.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 19 (estimated)
- First submitted
- 18 Apr 2025
- Start date
- 9 Jun 2025
- Primary completion date
- 28 Feb 2027
- Lead sponsor
- Medtronic Vascular
- Diseases
- High blood pressure
- NCT number
- NCT07013929
What you commit to
- Study type: Interventional
- Planned participants: 19
- From 9 Jun 2025 to the primary completion date, 28 Feb 2027
- 2 sites in 2 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Prior renal denervation.
- Individual is taking SGLT2 inhibitors or GLP-1 agonists
- Individual is currently taking anti-mineralocorticoid drugs.
Other illness
- Primary pulmonary hypertension.
- Secondary cause of hypertension
- Individual has a documented condition that would prohibit or interfere with ability to obtain an accurate blood pressure measurement
Lab values
- Individual has an estimated glomerular filtration rate (eGFR) of \<60 mL/min/1.73m2
Other
- Individual lacks appropriate renal artery Anatomy
- Has a renal artery stent
- Individual requires chronic oxygen support or mechanical ventilation
- Pregnant, nursing or planning to become pregnant during the study.
Who the study is looking for
- 20 - 70 years of age
- Office SBP ≥150 mmHg and \<180 mmHg and DBP ≥90 mmHg
- Individual is prescribed with one, two, or three antihypertensive medication classes
- 24-hour ABPM average of SBP ≥135 and \<170 mmHg at Baseline
Age in the registry: 20 years to 70 years · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hippokration General Hospital of Athens Coordinator of this site? Confirm its status | Athens | Greece | Recruiting |
| University Hospital Galway Coordinator of this site? Confirm its status | Galway | Ireland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.