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NCT07015060Not yet recruiting

Pathogenic Mechanisms Involved in the Initiation and Progression of Systemic Sclerosis

Source: ClinicalTrials.gov · Last updated 11 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open

Brief summary (registry, in English)

Identify rare variants in candidate genes and pathways identified in familial SSc, in patients with sporadic SSc. Perform (spatial) transcriptomic and proteomic analyses of affected skin from patients with and without cutaneous fibrosis, for the patterns and levels of expression/activation of candidate genes and pathways. Test for dysregulation of expression/activation of candidate genes and pathways in live cells isolated from the blood and skin biopsy of patients, and for the impact of these dysregulations on cell appearance, behavior and function.

Status (registry)
Not yet recruiting
Study type
Interventional
Enrollment
15 (estimated)
First submitted
22 May 2025
Start date
Jun 2025
Primary completion date
Sept 2030
Lead sponsor
Université Catholique de Louvain
NCT number
NCT07015060

What you commit to

  • Study type: Interventional
  • Planned participants: 15
  • From Jun 2025 to the primary completion date, Sept 2030
  • No sites listed in no country
  • Visits and tests: ask the trial team, the registry does not list them

Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.

Who cannot take part

Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.

Other illness

  • Other (co-occurring) autoimmune/autoinflammatory disease

Other

  • Pregnancy
  • Participants with temporary or definitive disabilities to give consent
  • Participants unable to sign or read the inform consent form

Who the study is looking for

  • Patients diagnosed with one of the following:
    • Limited SSc
    • Limited cutaneous SSc
    • Diffuse cutaneous SSc
  • Patients followed regularly in consultations at CUSL.
  • Patients between ages 18-80.

Age in the registry: 18 years to 80 years · Sex: All · Accepts healthy volunteers

Full criteria on ClinicalTrials.gov

This page is information, not medical advice. Discuss any trial with your doctor.