NCT07017478CompletedEarly phase 1
Mood Effects of Serotonin Agonists: Depression
Source: ClinicalTrials.gov · Last updated 10 Jul 2026
Brief summary (registry, in English)
This study will examine the effect of a low dose of the 5HT2A agonist LSD (26 µg), compared to placebo, on acute and protracted mood states in individuals with depression. The investigators will assess the relationship between mood-related symptoms and EEG as a neurophysiological marker.
- Status (registry)
- Completed
- Phase (registry)
- Early phase 1
- Study type
- Interventional
- Enrollment
- 41 (actual)
- First submitted
- 22 Apr 2025
- Start date
- 9 Jun 2025
- Primary completion date
- 1 Jun 2026
- Lead sponsor
- University of Chicago
- Diseases
- Depression
- NCT number
- NCT07017478
What you commit to
- Study type: Interventional · Early phase 1
- Participants enrolled: 41
- From 9 Jun 2025 to the primary completion date, 1 Jun 2026
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- currently taking any psychiatric medication (for conventional antidepressants must be off for ≥ 2 weeks)
Other illness
- individuals with a medical condition contraindicating study participation as determined by the study physician (e.g., liver disease, abnormal EKG, liver or cardiovascular disease)
- past year severe substance use disorder
- personal or first-degree relative with history of psychosis
- active panic disorder
- severe obsessive-compulsive disorder
- severe post-traumatic stress disorder
Other
- high blood pressure (\>140/90)
- current suicidal ideation or suicide attempt in past 12 months
- women who are pregnant or planning to become pregnant
Who the study is looking for
- English Fluency
- high school education or higher
- BMI between 19-30 kg/m2
Age in the registry: 18 years to 40 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Chicago Coordinator of this site? Confirm its status | Chicago | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.