NCT07019844Recruiting
PSMA PET for the Staging and Management of Hepatocellular Carcinoma
Addition of F18-Piflufolastat PET/CT to Cross-Sectional Imaging for the Staging and Management of Hepatocellular Carcinoma
Source: ClinicalTrials.gov · Last updated 26 Jun 2026
Brief summary (registry, in English)
This prospective, single-center study evaluates the clinical utility of F18-Piflufolastat (PSMA) PET/CT when added to conventional cross-sectional imaging for patients with suspected or confirmed hepatocellular carcinoma (HCC). The study aims to determine whether PSMA PET/CT improves diagnostic accuracy for indeterminate liver lesions (LI-RADS 3 and 4), enhances staging precision in treatment-naïve patients, and provides more accurate assessment of treatment response in patients undergoing locoregional therapy (LRT). The goal is to assess how PSMA PET/CT may impact clinical decision-making, staging, and management of HCC across multiple stages of disease.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 90 (estimated)
- First submitted
- 5 Jun 2025
- Start date
- Sept 2024
- Primary completion date
- Dec 2027
- Lead sponsor
- VA Office of Research and Development
- Diseases
- Liver and biliary tract cancer
- NCT number
- NCT07019844
What you commit to
- Study type: Observational
- Planned participants: 90
- From Sept 2024 to the primary completion date, Dec 2027
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Patients with renal dysfunction or contrast allergy that precludes contrast enhanced cross sectional imaging
- Patients with presence of active primary malignancy other than HCC and non-melanoma skin cancer in the past 3 years
Who the study is looking for
- Adult patients age \>18 years from the VA medical system
- Treatment-naïve patients with HCC with BCLC B or C disease
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Miami VA Healthcare System, Miami, FL Coordinator of this site? Confirm its status | Miami | United States | Recruiting |
| VA Greater Los Angeles Healthcare System, West Los Angeles, CA Coordinator of this site? Confirm its status | West Los Angeles | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.