NCT07021040Recruiting
Olfactory Biopsies
Analysis of Human Olfactory Biopsies
Source: ClinicalTrials.gov · Last updated 12 Jun 2026
Brief summary (registry, in English)
This research study aims to investigate the function of the olfactory lining in the nasal cavity and its potential alterations in both healthy and diseased conditions. The olfactory lining is involved in the sense of smell. The purpose of this study is to collect tissue from the nasal cavity.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 125 (estimated)
- First submitted
- 5 Jun 2025
- Start date
- 6 Jan 2025
- Primary completion date
- 30 Apr 2029
- Lead sponsor
- Duke University
- Diseases
- Alzheimer disease
- NCT number
- NCT07021040
What you commit to
- Study type: Interventional
- Planned participants: 125
- From 6 Jan 2025 to the primary completion date, 30 Apr 2029
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Other known sinonasal disease history that would preclude biopsy (i.e prior sinus or skull base surgery directly impacting this anatomic region, sinonasal neoplasm in this anatomic region, olfactory cleft polyps)
Other illness
- Advanced Alzheimer's/dementia
- Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
- Parkinson's disease
- Self-reported or known allergy to Afrin or Tetracain HCL (or related class of drugs)
Other
- Active Rhinosinusitis symptoms
- Unable or willing to complete the nasal endoscopy procedure.
- Unable to read or speak English
- Unable to provide legally effective consent
- Group 2: Act-seq study or Non-AD controls
- Unable or willing to complete the nasal endoscopy procedure
- Unable to read or speak English
- Unable to provide legally effective consent
Who the study is looking for
- Between the ages of 18 and 80
- Pre-clinical AD (this cohort consists of subjects who have normal cognitive testing and function, but have positive AD biomarkers);
- Symptomatic AD (a confirmed diagnosis of Alzheimer's or dementia who are capable of understanding and signing the consent document)
- Age 18 years or older
- Patients being seen for rhinology or olfactory disorders
- Patients having unrelated endoscopic nasal surgery
Criteria the registry did not label
- Group 1: Alzheimer's study
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Duke University Health Center Coordinator of this site? Confirm its status | Durham | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.