NCT07022626Completed
Trial to Assess Whether Computed Tomography Cardiac Angiography Can Improve Invasive Coronary Angiography in Bypass Surgery Patients
A Randomised Controlled Trial Assessing the Value of Computed Tomography Cardiac Angiography in Improving Patient Satisfaction and Reducing Contrast Load, Procedural Duration and Complications in Patients Who Had Previous Bypass Surgery Undergoing Coronary Angiography
Source: ClinicalTrials.gov · Last updated 15 Jun 2025
Brief summary (registry, in English)
A large number of patients with symptomatic ischaemic heart disease undergo coronary artery bypass grafting (CABG) to alleviate their symptoms and improve prognosis. Given the progressive nature of coronary disease, bypass grafts can narrow or block over time, leading to chest pain and the need for further invasive coronary angiography. Invasive coronary procedures in patients with bypass grafts can be more complicated due to the variation in bypass graft ostia. This can lead to longer procedure times, with higher doses of contrast and radiation and more discomfort for the patient. The aim of this study is to see if the use of computed tomography coronary angiography (CTCA) in patients with previous bypass grafts prior to invasive coronary angiography will help make their procedure safer and quicker.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 688 (actual)
- First submitted
- 4 Nov 2024
- Start date
- 14 Nov 2018
- Primary completion date
- 28 Feb 2024
- Lead sponsor
- Barts & The London NHS Trust
- Diseases
- Coronary artery disease
- NCT number
- NCT07022626
What you commit to
- Study type: Interventional
- Participants enrolled: 688
- From 14 Nov 2018 to the primary completion date, 28 Feb 2024
- 2 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Subjects presenting with ST elevation myocardial infarction, cardiogenic shock (systolic blood pressure \<80 mmHg for \>30 minutes, or requiring inotropes or emergency intra aortic balloon pump for hypotension treatment) or cardiopulmonary resuscitation.
- Current life-threatening condition other than vascular disease that may prevent a subject completing the study.
- Clinical instability including cardiogenic shock, hypotension (low blood pressure-systolic blood pressure less than 90 mmHg), sustained ventricular or atrial arrhythmia requiring intravenous medications.
- Inability to tolerate beta-blockers, including those with chronic obstructive pulmonary disease or asthma, complete heart block, second-degree atrioventricular block
- Known contrast dye allergy.
Lab values
- Subjects with eGFR \<20ml/min or on renal replacement therapy.
- Patients considered unsuitable to participate by the research team (e.g., due to medical reasons, laboratory abnormalities, or subject's unwillingness to comply with all study related procedures).
Other
- Pregnancy or unknown pregnancy status.
- Inability or refusal to provide informed consent.
- Any inclusion criteria not met
Who the study is looking for
- Patients undergoing coronary angiography +/-Percutaneous coronary Intervention
- Previous Coronary Artery Bypass Grafting (CABG)
- Aged ≥18
- Patients able and willing to give their written informed consent.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (2)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| St. Bartholomew's Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
| Royal London Hospital Coordinator of this site? Confirm its status | London | United Kingdom | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.