NCT07024875Recruiting
Neuroimaging of Parkinson's
Precision Neuroimaging of Parkinson's Disease
Source: ClinicalTrials.gov · Last updated 13 Apr 2026
Brief summary (registry, in English)
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network (SCAN), which could be a primary locus of dysfunction in PD. Here, the investigators will use magnetic resonance imaging techniques in PD patients to test whether SCAN is critical for PD. The investigators will determine whether SCAN is connected to PD-relevant subcortical structures, and whether PD patients exhibit altered subcortical-to-SCAN connectivity. If successful, this work will identify SCAN as a specific circuit altered in PD patients that can serve as a new target for future neuromodulatory PD therapies.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 120 (estimated)
- First submitted
- 9 Jun 2025
- Start date
- 1 Aug 2025
- Primary completion date
- 31 Jan 2031
- Lead sponsor
- Washington University School of Medicine
- Diseases
- Parkinson disease
- NCT number
- NCT07024875
What you commit to
- Study type: Observational
- Planned participants: 120
- From 1 Aug 2025 to the primary completion date, 31 Jan 2031
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- MRI contraindications
- Metal implants
- claustrophobia
- Weight over 300 lbs (due to weight restrictions of the MRI scanner)
Other illness
- Neurological Disorders (other than PD)
- \- Any other neurological condition
- Psychiatric Disorders
- Schizophrenia
- Bipolar Disorder
- Epilepsy
- Serious Medical Conditions
- End-stage organ failure
- Ongoing cancer treatment
- Cognitive Impairment
- Diagnosis of dementia
- MMSE score \<24 or MoCA score \<21
Other
- Significant Head Injury
- Head injury with loss of consciousness \>5 minutes
- Or any neurological sequelae
Who the study is looking for
- Must meet specific health and cognitive criteria depending on the group. For PD participants
- Clinical diagnosis of Parkinson's Disease
- Must not meet dementia criteria For Healthy Control Participants
- Normal or benign neurological exam
- Normal cognition
- No first-degree relatives with Parkinson's Disease
Age in the registry: 40 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| East Imaging Building Coordinator of this site? Confirm its status | St Louis | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.