The Link Between Physical Activity and Brain Health in Healthy Adults

Prior treatment

• Severe head injury with loss of consciousness within the previous 5 years.
• Those with pacemakers or metallic implants that may interfere with the MRI.

Other illness

• Medical conditions that have a high risk of associated cognitive symptoms.
• Hearing or visual impairment that would preclude testing
• History of neurological disease with clinically relevant impact on cognition (e.g. cerebrovascular disease).
• Incidental structural brain findings with impact on cognitive impairment or survival (e.g., malignant brain tumor).
• Presence of severe systemic disease (e.g., cancer under treatment).

Other

• Alcoholism (\>3 alcoholic drinks per day).
• Chronic use of anxiolytics, neuroleptics, narcotics, anticonvulsants, or sedative hypnotics.
• Consumption of anabolic substances.
• Problems understanding spoken or written Spanish.

• Group A: ex-athletes and continue to perform regular physical exercise (minimum 3 days/week of moderate-vigorous intensity).
• Group B: sedentary individuals, (i.e., perform \<150 min of moderate intensity exercise per week or IPAQ score\<600 MET min/week).
• In both groups (A and B) the conditions of physical exercise or sedentary lifestyle must have been maintained for at least 6 months prior to the evaluations.
• Not having a history of neurological or psychiatric disorder or suffering from a serious medical condition