NCT07028489Recruiting
Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer
Source: ClinicalTrials.gov · Last updated 22 Sept 2026
Brief summary (registry, in English)
The objective of this study is to build a prospective cohort in patients with locally advanced or metastatic NSCLC with common EGFR mutations. In NPM-002, there will be standardized data collection at baseline, on-treatment and at discontinuation of therapy. Patients who enroll prior to initiation of osimertinib treatment (\~30%) will undergo imaging with standardized intervals.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 130 (estimated)
- First submitted
- 9 Jun 2025
- Start date
- 5 Jun 2025
- Primary completion date
- 31 Dec 2028
- Lead sponsor
- N-Power Medicine
- Diseases
- Lung cancer
- NCT number
- NCT07028489
What you commit to
- Study type: Observational
- Planned participants: 130
- From 5 Jun 2025 to the primary completion date, 31 Dec 2028
- 10 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Evidence of prior treatment with osimertinib, amivantamab or lazertinib. For the planned selection and analysis of external controls, further eligibility criteria will be applied according to the COPERNICUS SAP.
Other
- ECOG≥2 at diagnosis of advanced or metastatic NSCLC
Who the study is looking for
- Be ≥18 years of age at the time of informed consent
- Evidence of a confirmed diagnosis of EGFR mutant (EGFR exon 19del or EGFR exon 21 L858R) locally advanced or metastatic NSCLC diagnosed on Jan 1st 2024 or later.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (10)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| New Mexico Oncology Hematology Consultants Coordinator of this site? Confirm its status | Albuquerque | United States | Recruiting |
| Kootenai Clinic Cancer Services Coeur d'Alene Coordinator of this site? Confirm its status | Coeur d'Alene | United States | Recruiting |
| Bayhealth Cancer Center- Kent Coordinator of this site? Confirm its status | Dover | United States | Recruiting |
| Northwest Oncology & Hematology Coordinator of this site? Confirm its status | Elk Grove Village | United States | Recruiting |
| Oncology Consultants, P.A. Coordinator of this site? Confirm its status | Houston | United States | Recruiting |
| Bayhealth Cancer Center- Sussex Coordinator of this site? Confirm its status | Milford | United States | Recruiting |
| Pacific Cancer Care Coordinator of this site? Confirm its status | Monterey | United States | Recruiting |
| Lankenau Medical Center Coordinator of this site? Confirm its status | Paoli | United States | Not yet recruiting |
| Torrance Memorial Physician Network - Cancer Care Coordinator of this site? Confirm its status | Torrance | United States | Recruiting |
| John Muir Health Coordinator of this site? Confirm its status | Walnut Creek | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.