A Study of LY3549492 in Adults With Obesity or Overweight With Type 2 Diabetes

Prior treatment

• Have any of the following cardiovascular conditions within 6 months prior to screening:
  • acute myocardial infarction
  • cerebrovascular accident (stroke)
  • unstable angina, or
  • hospitalization due to congestive heart failure.
  • W8M-MC-CWMM:
• Have a prior or planned surgical treatment for obesity, except prior liposuction or abdominoplasty, if performed >1 year prior to screening

Other illness

• Have a history of acute or chronic pancreatitis
• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history of ketoacidosis or hyperosmolar coma
• Have poorly controlled hypertension
• Have signs and symptoms of any liver disease other than nonalcoholic fatty liver disease
• Have a history of symptomatic gallbladder disease within the past 2 years
• Have a lifetime history of suicide attempts

Other

• W8M-MC-GN02:
• Individuals who are of childbearing potential

• W8M-MC-GN02:
• Assigned male at birth
• Assigned female at birth, who are of non-childbearing potential
• Have type 2 diabetes
  • W8M-MC-CWMM:
• Have a BMI ≥27 kilograms per square meter (kg/m²)
• Have had a stable body weight for the 3 months prior to randomization (<5% body weight gain and/or loss