NCT07031102Recruiting
Methacholine Challenge Test in School Children With/Without Asthma RISKA
RISKA: Respiratory Irritability With School Kids With/Without Asthma - Assessment of Methacholine Responsiveness in Pediatric Asthma: A Comparative Study With Healthy Controls
Source: ClinicalTrials.gov · Last updated 22 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The study includes a pre-study telephone interview with healthy controls to assess their eligibility for participation. During the study visit, a background information form and an asthma questionnaire are completed. At the study visit, a methacholine challenge test measuring airway hyperresponsiveness and an exhaled nitric oxide measurement are performed. The effect of medication intensification in asthma patients is further assessed through a telephone interview 1-2 months after the medication adjustment.
- Status (registry)
- Recruiting
- Study type
- Observational
- Enrollment
- 260 (estimated)
- First submitted
- 30 May 2025
- Start date
- Nov 2024
- Primary completion date
- Dec 2027
- Lead sponsor
- Helsinki University Central Hospital
- Diseases
- Asthma
- NCT number
- NCT07031102
What you commit to
- Study type: Observational
- Planned participants: 260
- From Nov 2024 to the primary completion date, Dec 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- • Premature birth before 32 gestational weeks
- Other chronic cardiopulmonary or neurological conditions affecting airways (excluding asthma)
- Severe underlying illness such as malignancy
- Beta-blocker medication
- Active immunological disease
Who the study is looking for
- • Aged 7-15 years, both sexes
- No diagnosis of asthma in childhood
- No inhaled asthma medication during the previous 2 years
- No wheezing or shortness of breath during the previous 2 years
- Written informed consent from the participant and guardian
- Aged 7-15 years, both sexes
- Physician-diagnosed asthma (ICD-10 codes J45.0/J45.1/J45.9)
- Inhaled corticosteroid treatment for at least 6 months
- Either:
- Well-controlled asthma (c-ACT/ACT score ≥20) and no clinical need to intensify medication, or
- Poorly controlled asthma with physician-confirmed need for intensified asthma medication
Age in the registry: 7 years to 15 years · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| HUS Skin and Allergy Hospital Coordinator of this site? Confirm its status | Helsinki | Finland | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.