NCT07032064Completed
Evaluation of Electrical and Hemodynamic Effects of Different Pacing Strategies in CRT Candidates
Electrical and Hemodynamic Assessment of Pacing Modalities in Patients With Indications for Cardiac Resynchronization Therapy
Source: ClinicalTrials.gov · Last updated 22 Jun 2025
Brief summary (registry, in English)
Heart failure patients with delayed electrical activation of the heart often benefit from cardiac resynchronization therapy (CRT). However, traditional CRT using biventricular pacing is not effective in all patients. This study aims to evaluate the acute effects of pacing at different sites within the heart's conduction system-including His bundle pacing, deep septal pacing, left ventricular septal pacing, non-selective left bundle branch pacing, and selective left bundle branch pacing. We will assess how these pacing strategies improve electrical synchrony and heart function by analyzing ECG parameters, such as QRS duration and QRS area, and measuring hemodynamic response using left ventricular pressure changes. The goal is to identify which pacing site provides the best improvement in heart performance. The study includes patients with left bundle branch block or intraventricular conduction delay, reduced heart function (ejection fraction \<35%), and prolonged QRS duration (\>150 ms). This research may help improve the effectiveness of pacing therapy in heart failure patients who are not responding well to current CRT methods.
- Status (registry)
- Completed
- Study type
- Interventional
- Enrollment
- 28 (actual)
- First submitted
- 13 Jun 2025
- Start date
- 3 Jun 2024
- Primary completion date
- 20 May 2025
- Lead sponsor
- Shanghai Zhongshan Hospital
- Diseases
- Heart failure
- NCT number
- NCT07032064
What you commit to
- Study type: Interventional
- Participants enrolled: 28
- From 3 Jun 2024 to the primary completion date, 20 May 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- second- or third-degree AV block, frequent PVCs, moderate-to-severe aortic stenosis, LV thrombus, or significant peripheral vascular disease
Who the study is looking for
- NYHA class I to ambulatory IV despite optimized medical therapy for ≥3 months, LVEF ≤35%, and sinus rhythm with LBBB. LBBB was defined as QRS duration ≥130 ms, QS or rS in lead V1, broad/notched R waves in leads I, aVL, V5-V6, and absence of q waves in V5-V6
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Zhongshan Hospital,Fudan University Coordinator of this site? Confirm its status | Shanghai | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.