NCT07032571Not yet recruiting
Reset: Enhancing Weight Loss in a Digital Intervention
Enhancing Weight Loss in a Digital Intervention Among Adults With Overweight or Obesity
Source: ClinicalTrials.gov · Last updated 4 Aug 2026
Brief summary (registry, in English)
The goal of the Reset trial is to learn about the optimal combination of dietary behavior strategies in a fully digital weight loss intervention. The intervention is designed for adults with overweight or obesity. The investigators will examine the impact on weight loss of four dietary strategies: 1) limiting Red Zone Foods (i.e., foods that are high in calories and low in nutrition), 2) limiting eating windows, 3) increasing protein intake, and 4) increasing fiber intake. Each of these strategies will include goal setting, daily self-monitoring, and tailored feedback. The investigators will recruit 208 participants. Broadly, adults with overweight or obesity who live in the U.S. will be eligible. The weight loss intervention will last 12 weeks. All participants will be asked to track their body weight daily and complete weekly behavioral lessons and action plans to promote healthy eating and physical activity. All study tasks will occur remotely. Assessment of body weight and survey measures will occur at the beginning of the trial ("baseline"), and at 1 month and 3 months. The Multiphase Optimization Strategy (MOST) framework will be used to identify which combination of the dietary behavior strategies results in the greatest weight loss. In total, there will be 16 treatment conditions.
- Status (registry)
- Not yet recruiting
- Study type
- Interventional
- Enrollment
- 208 (estimated)
- First submitted
- 15 Jun 2025
- Start date
- 1 Sept 2026
- Primary completion date
- 31 Mar 2027
- Lead sponsor
- Stanford University
- Diseases
- Obesity
- NCT number
- NCT07032571
What you commit to
- Study type: Interventional
- Planned participants: 208
- From 1 Sept 2026 to the primary completion date, 31 Mar 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- concurrent enrollment in another weight management intervention
- current use of a weight loss or anti-obesity medication
- prior or planned bariatric surgery in the next 3 months
Other illness
- hospitalization for a mental health condition in the past 12 months
- if weight loss is contraindicated or might be impacted by a condition (e.g., end stage renal disease, cancer, schizophrenia, dementia) or medication (e.g., steroids, antipsychotics)
- if an individual would be better suited for a more intensive or different type of intervention based on a health condition (e.g., individuals with history of an eating disorder or cardiovascular event, uncontrolled hypertension, or uncontrolled diabetes mellitus)
Other
- loss of ≥5% body weight in the past 6 months
- current pregnancy, planned pregnancy in the next 3 months, or recent pregnancy in the past 6 months
- current breastfeeding or lactating
- living with someone else participating in the study
- inability to engage in moderate forms of physical activity akin to brisk walking
- participation in another weight loss study conducted in Dr. Patel's lab in the past 6 months
- investigator discretion for safety reasons
Who the study is looking for
- adults (ages 18+ years)
- body mass index (BMI) 25.0 to 45.0 kg/m\^2
- cellphone ownership with a texting plan
- daily access to a personal scale
- daily access to a personal email account
- English language proficiency
- interest in losing weight through behavioral strategies
- living in the United States
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Stanford University, School of Medicine Coordinator of this site? Confirm its status | Palo Alto | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.