NCT07033559Not yet recruiting
Detecting Fatigue From Voice in Generalised Myasthenia Gravis
Remote Digital Voice Biomarkers for Central Fatigue Detection in Generalised Myasthenia Gravis: An Online Single-Cohort Observational Study
Source: ClinicalTrials.gov · Last updated 28 Jan 2026
Brief summary (registry, in English)
The goal of this observational study is to learn if computer analysis of voice recordings can detect a type of exhaustion called "central fatigue" in adults with generalised myasthenia gravis. The main questions it aims to answer are: 1. Can advanced voice analysis accurately tell when participants are experiencing deep exhaustion based on how they speak? 2. How easy and acceptable is voice-based fatigue monitoring for people with myasthenia gravis? Participants will: 1. Record themselves reading short passages and answering questions out loud twice daily (morning and evening), twice a week, for 4 weeks. 2. Answer brief questionnaires about their energy levels, mood, and myasthenia gravis symptoms during each session. 3. Use their own devices (computer, tablet, or smartphone) to complete all study activities online from home.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 240 (estimated)
- First submitted
- 3 Jun 2025
- Start date
- 1 Feb 2026
- Primary completion date
- 30 Jun 2026
- Lead sponsor
- Thymia Limited
- Diseases
- Myasthenia gravis
- NCT number
- NCT07033559
What you commit to
- Study type: Observational
- Planned participants: 240
- From 1 Feb 2026 to the primary completion date, 30 Jun 2026
- No sites listed in no country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Unable to provide credible diagnostic information (healthcare provider diagnosis, antibody test results, current medications)
Other illness
- Diagnosed mild cognitive impairment or dyslexia
Other
- Pure ocular Myasthenia Gravis
- Speech or hearing impairments affecting voice recording
- Major inconsistencies in reported medical history
- Unsigned informed consent
Who the study is looking for
- Adults ≥18 years old
- Self-reported generalised Myasthenia Gravis diagnosis confirmed by healthcare provider for ≥6 months
- Disease stability for ≥6 months (no hospitalisations, medication changes, or significant symptom worsening)
- English as first language
- Residence in US or UK
- Vision adequate for screen reading (with aid or correction if necessary)
- Access to internet-connected device with compatible browser and microphone
- Adequate internet connectivity (≥5 Mbps download, ≥3 Mbps upload)
- Ability to complete twice-daily assessments during specified time windows
- Signed electronic informed consent
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
This page is information, not medical advice. Discuss any trial with your doctor.