NCT07033988Not yet recruiting
Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia
Insights Into Cerebral Clot Biomarkers and Inflammatory Pathways
Source: ClinicalTrials.gov · Last updated 24 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
This is an observational, prospective and retrospective, single-center study of thrombotic material and blood samples obtained from patients undergoing mechanical endovascular thrombectomy for ischemic stroke caused by large vessel occlusion or stenosis. The overarching aim of this study is to advance the understanding of the pathogenesis of cerebral ischemia and to support the development of novel therapeutic strategies for cerebrovascular disease. Specifically, the research seeks to elucidate the pathophysiological mechanisms involved in thrombus formation and stabilization that lead to ischemic events, identify thrombus compositions associated with distinct stroke etiologies, and determine features predictive of resistance to current intravenous thrombolytic therapies. In addition, the study aims to discover novel therapeutic targets and to identify circulating blood biomarkers indicative of an elevated risk of thrombosis.
- Status (registry)
- Not yet recruiting
- Study type
- Observational
- Enrollment
- 380 (estimated)
- First submitted
- 4 Jun 2025
- Start date
- Jun 2025
- Primary completion date
- May 2030
- Lead sponsor
- IRCCS San Raffaele
- Diseases
- Stroke
- NCT number
- NCT07033988
What you commit to
- Study type: Observational
- Planned participants: 380
- From Jun 2025 to the primary completion date, May 2030
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Presence of a known autoimmune disease that could interfere with the interpretation of biomarker analyses
Other
- Pregnancy or breastfeeding
Who the study is looking for
- Age ≥ 18 years.
- Presentation to the emergency department with symptoms and/or signs suggestive of:
- An acute cerebrovascular event
- Stroke mimics
- Stroke-related risk factors (e.g., atrial fibrillation, endocarditis, significant internal carotid stenosis, neoplasms, systemic infections)
- Undergoing one of the following treatments:
- Mechanical thrombectomy
- Intravenous thrombolysis
- Standard medical therapy
- Provision of informed consent, either:
- Directly from the conscious patient
- Via appropriate procedures for unconscious patients
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Neurology Coordinator of this site? Confirm its status | Milan | Italy | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.