NCT07035093Active, not recruitingPhase 3
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Retatrutide Once Weekly in Participants Who Have Obesity or Overweight and Chronic Low Back Pain
Source: ClinicalTrials.gov · Last updated 25 Sept 2026
Brief summary (registry, in English)
The main purpose of this study is to evaluate the efficacy and safety of retatrutide in relieving chronic low back pain in participants who have obesity or overweight. Participation in the study will last about 80 weeks.
- Status (registry)
- Active, not recruiting
- Phase (registry)
- Phase 3
- Study type
- Interventional
- Enrollment
- 586 (estimated)
- First submitted
- 28 May 2025
- Start date
- 29 May 2025
- Primary completion date
- Sept 2027
- Lead sponsor
- Eli Lilly and Company
- Diseases
- Obesity
- NCT number
- NCT07035093
- EU CT number
- 2024-517431-43-00
What you commit to
- Study type: Interventional · Phase 3
- Planned participants: 586
- From 29 May 2025 to the primary completion date, Sept 2027
- 46 sites in 4 countries
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Have had botulinum or steroid injections to the spine within 1 year of screening
- Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days prior to screening
- Have been taking drugs to promote body weight reduction, including over-the-counter medications, within 90 days prior to screening
- Have a prior or planned surgical treatment for obesity
Other illness
- Have Type 1 Diabetes, Type 2 Diabetes, or any other type of diabetes
Other
- Have a non-axial origin low back pain
- Have had trigger point injection to the spine within 6 months of screening
Who the study is looking for
- Have a history of axial-predominant low back pain
- Have pain that is restricted to the low back or with a referral pattern limited to the proximal legs
- Have a body mass index (BMI) ≥27 kilograms per square meter (kg/m2) at screening
- Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (46)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Fundacion Respirar Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro Médico Viamonte Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Investigaciones Medicas Imoba Srl Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| CIPREC Coordinator of this site? Confirm its status | Buenos Aires | Argentina | Unknown status |
| Centro de Investigaciones Clínicas Baigorria Coordinator of this site? Confirm its status | Granadero Baigorria | Argentina | Unknown status |
| Centro Rosarino de Investigaciones Clinicas (CRICs) Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Instituto Médico Catamarca IMEC Coordinator of this site? Confirm its status | Rosario | Argentina | Unknown status |
| Centro de Diagnóstico y Rehabilitación (CEDIR) Coordinator of this site? Confirm its status | Santa Fe | Argentina | Unknown status |
| Aggarwal and Associates Limited Coordinator of this site? Confirm its status | Brampton | Canada | Unknown status |
| Winterberry Research Inc. Coordinator of this site? Confirm its status | Hamilton | Canada | Unknown status |
| Bluewater Clinical Research Group Inc. Coordinator of this site? Confirm its status | Sarnia | Canada | Unknown status |
| Care Access - Cape Breton Coordinator of this site? Confirm its status | Sydney | Canada | Unknown status |
| Dr. Anil K. Gupta Medicine Professional Corporation Coordinator of this site? Confirm its status | Toronto | Canada | Unknown status |
| Revit Sp. z o.o. Coordinator of this site? Confirm its status | Bialystok | Poland | Completed |
| Diamond Clinic Sp. z o.o. Coordinator of this site? Confirm its status | Cracow | Poland | Completed |
| Centrum Badan Klinicznych PI-House sp. z o.o. Coordinator of this site? Confirm its status | Gdansk | Poland | Completed |
| Santa SP. z o.o Coordinator of this site? Confirm its status | Lodz | Poland | Completed |
| Terpa Sp. z o.o. Sp. k. Coordinator of this site? Confirm its status | Lublin | Poland | Completed |
| Centrum Zdrowia Metabolicznego Paweł Bogdański Coordinator of this site? Confirm its status | Poznan | Poland | Completed |
| Medicover Integrated Clinical Services Sp. z o.o. Coordinator of this site? Confirm its status | Warsaw | Poland | Completed |
| FutureSearch Trials of Neurology Coordinator of this site? Confirm its status | Austin | United States | Unknown status |
| Great Lakes Research Group, Inc. Coordinator of this site? Confirm its status | Bay City | United States | Unknown status |
| Alpine Clinical Research Center Coordinator of this site? Confirm its status | Boulder | United States | Unknown status |
| MD First Research - Chandler Coordinator of this site? Confirm its status | Chandler | United States | Unknown status |
| Mercy Family Clinic Coordinator of this site? Confirm its status | Dallas | United States | Unknown status |
| Sovah Clinical Research-River District Coordinator of this site? Confirm its status | Danville | United States | Unknown status |
| K2 Medical Research - Daytona Beach Coordinator of this site? Confirm its status | Daytona Beach | United States | Unknown status |
| Altoona Center For Clinical Research Coordinator of this site? Confirm its status | Duncansville | United States | Unknown status |
| Ark Clinical Research, Fountain Valley Coordinator of this site? Confirm its status | Fountain Valley | United States | Unknown status |
| St. Joseph Heritage Healthcare Coordinator of this site? Confirm its status | Fullerton | United States | Unknown status |
| Houston Research Institute Coordinator of this site? Confirm its status | Houston | United States | Unknown status |
| New Phase Research And Development Coordinator of this site? Confirm its status | Knoxville | United States | Unknown status |
| Care Access - Lake Charles (Bayou Pines) Coordinator of this site? Confirm its status | Lake Charles | United States | Unknown status |
| Clinical Research Institute Coordinator of this site? Confirm its status | Los Angeles | United States | Unknown status |
| Flourish Research - Miami, LLC Coordinator of this site? Confirm its status | Miami | United States | Unknown status |
| Artemis Institute for Clinical Research Coordinator of this site? Confirm its status | San Diego | United States | Unknown status |
| Clinvest Headlands LLC Coordinator of this site? Confirm its status | Springfield | United States | Unknown status |
| IMA Clinical Research St. Petersburg Coordinator of this site? Confirm its status | St. Petersburg | United States | Unknown status |
| Care Access - Tampa Coordinator of this site? Confirm its status | Tampa | United States | Unknown status |
| Charter Research - Lady Lake Coordinator of this site? Confirm its status | The Villages | United States | Unknown status |
| Cotton O'Neil Clinical Research Center Coordinator of this site? Confirm its status | Topeka | United States | Unknown status |
| Tucson Orthopaedic Institute - North Wyatt Drive Coordinator of this site? Confirm its status | Tucson | United States | Unknown status |
| MedVadis Research Corporation Coordinator of this site? Confirm its status | Waltham | United States | Unknown status |
| Center for Clinical Research Coordinator of this site? Confirm its status | Winston-Salem | United States | Unknown status |
| Conquest Research Coordinator of this site? Confirm its status | Winter Park | United States | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.