NCT07035262Active, not recruiting
Impact of Pre- and Post-operative Serum Metabolome Dynamics in Colorectal Resection Outcomes
Preoperative and Postoperative Changes in Serum Metabolome Dynamics in Colorectal Cancer Patients and Their Impact on Perioperative Clinical Outcomes
Source: ClinicalTrials.gov · Last updated 25 Jun 2025
Brief summary (registry, in English)
The aim of this study is to systematically analyze the dynamic pattern of preoperative and postoperative serum metabolites in colorectal cancer patients through metabolomics technology, and to screen the key metabolites with statistical differences and explore their correlation with surgical interventions by combining the baseline characteristics of the patients with the perioperative clinical data; to further reveal the impact of surgery on the body's metabolic remodeling pattern, and to explore the potential biomarkers and regulatory pathways, providing a theoretical basis for elucidating the metabolic mechanism. Investigaters will further reveal the impact of surgery on metabolic remodeling, explore potential biomarkers and regulatory pathways, provide theoretical basis for elucidating the metabolic mechanism, and evaluate its clinical translational value (e.g., postoperative monitoring, targeted intervention, etc.), so as to lay the foundation for the subsequent basic research and precise treatment strategies.
- Status (registry)
- Active, not recruiting
- Study type
- Observational
- Enrollment
- 400 (actual)
- First submitted
- 16 Jun 2025
- Start date
- 1 Jan 2023
- Primary completion date
- 1 Jun 2025
- Lead sponsor
- Dong Peng
- Diseases
- Colorectal cancer
- NCT number
- NCT07035262
What you commit to
- Study type: Observational
- Participants enrolled: 400
- From 1 Jan 2023 to the primary completion date, 1 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Missing baseline data (age, BMI, gender, previous medical history, etc.);
Other illness
- Have or have had a previous history of other malignancies;
- Have a history of radiotherapy treatment;
- Have a history of inflammatory bowel disease;
- Have a familial history of genetic disorders;
Other
- Failed to leave the hospital earlier than medically indicated;
- Failed to sign an informed consent form.
Who the study is looking for
- Previous consent to participate;
- Blood drawn and serum samples extracted and preserved both preoperatively and postoperatively;
- Successful detection of metabolomics profiles from serum samples;
- Acceptance of a standard radical colorectal cancer procedure;
- Complete perioperative data available;
- Adults with a pathologic diagnosis of colorectal cancer
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| The First Affiliated Hospital of Chongqing Medical University Coordinator of this site? Confirm its status | Chongqing | China | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.