NCT07037524Not yet recruitingPhase 1/2
Low Dose Radiotherapy for Heart Failure
Prospective Pilot Single-center Study to Evaluate the Safety and Efficacy of Low-dose Radiotherapy in Patients With Heart Failure
Source: ClinicalTrials.gov · Last updated 25 Jun 2025 · Not updated for over 12 months - ask the site whether it is still open
Brief summary (registry, in English)
The primary goals of this clinical trial are to evaluate the safety and efficacy of a low dose whole-heart radiotherapy with a single fraction in ten participants with advanced heart failure.
- Status (registry)
- Not yet recruiting
- Phase (registry)
- Phase 1/2
- Study type
- Interventional
- Enrollment
- 10 (estimated)
- First submitted
- 17 Jun 2025
- Start date
- 14 Jul 2025
- Primary completion date
- 20 Dec 2025
- Lead sponsor
- Hospital do Coracao
- Diseases
- Heart failure
- NCT number
- NCT07037524
What you commit to
- Study type: Interventional · Phase 1/2
- Planned participants: 10
- From 14 Jul 2025 to the primary completion date, 20 Dec 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Patients who have undergone any type of previous radiotherapy in the thoracic region;
- Contraindications for magnetic resonance imaging (MRI), such as the use of metal implants or prostheses.
Other illness
- Patients who have undergone heart transplants;
Other
- Pregnant patients.
Who the study is looking for
- Age \>18 years;
- Clinical and laboratory diagnosis of chronic systolic HF grades II or III of the New York Heart Association with ejection fraction \<40%;
- Refractoriness to standard clinical treatment; defined as the persistence of HF signs and symptoms despite optimized drug therapy.
- Patient consent to participate in the study.
- Agreement to adopt contraceptive practices/methods until the end of the intervention for women of childbearing age.
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Hcor / Associação Beneficente Síria Coordinator of this site? Confirm its status | São Paulo | Brazil | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.