NCT07037706Completed
Use of Macrolides in Acute Chest Syndrome: A Multicenter Retrospective Study
Source: ClinicalTrials.gov · Last updated 25 Jun 2025
Brief summary (registry, in English)
This study looks at whether using macrolide antibiotics is helpful and safe in treating acute chest syndrome, a serious complication in people with sickle cell disease. It reviews past cases from three hospitals where patients were treated in intensive care. The goal is to understand if macrolides make a difference, what germs are involved, how useful lab tests are, and how well patients tolerate these antibiotics.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 250 (actual)
- First submitted
- 11 Jun 2025
- Start date
- 1 Jun 2023
- Primary completion date
- 1 Jun 2024
- Lead sponsor
- Centre Hospitalier de Saint-Denis
- Diseases
- Sickle cell disease
- NCT number
- NCT07037706
What you commit to
- Study type: Observational
- Participants enrolled: 250
- From 1 Jun 2023 to the primary completion date, 1 Jun 2024
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- Acute chest syndrome not requiring ICU admission.
- Acute chest syndrome without any attempt at microbiological documentation.
Age
- Minor patient (\<18 years old).
Who the study is looking for
- Adult patient (≥18 years old).
- Diagnosis of acute chest syndrome (ACS).
- Hospitalized in an intensive care unit (ICU).
- Microbiological sampling performed (e.g., multiplex PCR, sputum culture \[ECBC\], and/or Legionella urinary antigen test).
- Received empiric antibiotic therapy including a macrolide.
Age in the registry: 18 years to - · Sex: All
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| France Coordinator of this site? Confirm its status | Saint-Denis | France | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.